Transforming Growth Factor

The name "Transforming Growth Factor" is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different Receptor Mechanisms . Furthermore, they do not always induce cellular transformation, and are not the only growth factors that induce Cellular Transformation .

TYPES

TGFα is upregulated in some human Cancer s. It is produced in Macrophage s, Brain cells, and Keratinocyte s, and induces Epithelial development.

TGFβ exists in three known subtypes in humans, TGFβ1, TGFβ2, and TGFβ3. These are upregulated in some human cancers, and play crucial roles in Tissue Regeneration , Cell Differentiation , Embryonic Development , and regulation of the Immune System . TGFβ Receptors are single pass Serine/threonine Kinase Receptor s.

FUNCTION

These proteins were originally characterized by their capacity to induce Oncogenic Transformation in a specific Cell Culture system, rat kidney fibroblasts. Application of the transforming growth factors to normal Rat Kidney Fibroblasts induces the cultured cells to proliferate and overgrow, no longer subject to the normal inhibition caused by contact between cells.

SEE ALSO

Bone Morphogenetic Protein

TGF Beta Signaling Pathway

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Transforming Growth Factor