Information AboutThromboxane |
| CATEGORIES ABOUT THROMBOXANE | |
| eicosanoids | |
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]] Thromboxane is a member of the family of Lipids known as Eicosanoids . The two major thromboxanes are Thromboxane A2 and Thromboxane B2 . Thromboxane is named for its role in clot formation ( Thrombosis ). PRODUCTION It is produced in Platelet s by Thromboxane-A Synthase from the Endoperoxide s produced by the Cyclooxygenase (COX) enzyme from Arachidonic Acid . FUNCTIONS Thromboxane is a Vasoconstrictor and a potent hypertensive agent, and it facilitates platelet aggregation. It is in Homeostatic balance in the Circulatory System with Prostacyclin , a related compound. ROLE OF A2 IN PLATELET AGGREGATION Thromboxane A2 (TXA2), produced by activated platelets, has prothrombotic properties, stimulating activiation of new platelets as well as increasing platelet aggregation. Platelet aggregation is achieved by mediating expression of the glycoprotein complex GP IIb/IIIa in the cell membrane of platelets. Circulating Fibrinogen binds these receptors on adjacent platelets, further strengthening the Clot . PATHOLOGY It is believed that the vasoconstriction caused by thromboxanes plays a role in Prinzmetal's Angina . SUPPRESSION The widely used drug Aspirin acts by inhibiting the ability of the COX enzyme to synthesize the precursors of thromboxane within platelets. It inhibits the COX enzyme both non-competitively and irreversibly. The side effect of this is that people who regularly take aspirin will suffer from excessive bleeding whenever the skin is perforated. EXTERNAL LINKS |
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