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DEFINITION OF SIRS

Criteria for SIRS were agreed in 1992.1 SIRS can be diagnosed when two or more of the following are presentIrwin RS, Cerra FB, Rippe JM. Irwin and Rippe's Intensive Care Medicine. 5th Ed. Lippincott Williams & Wilkins. Hagerstown, MD. 2003. ISBN 0-7817-1425-7. Publisher's information on the book .Marino PL. The ICU Book. 2nd Ed. Lippincott Williams & Wilkins. Hagerstown, MD. 1998. ISBN 0-683-05565-8. Publisher's information on the book .Sharma S, Steven M. Septic Shock. eMedicine.com, URL: http://www.emedicine.com/MED/topic2101.htm Accessed on Nov 20, 2005.Tslotou AG, Sakorafas GH, Anagnostopoulos G, Bramis J. Septic shock; current pathogenetic concepts from a clinical perspective. Med Sci Monit. 2005 Mar;11(3):RA76-85. PMID 15735579. Full Text .:
  • Heart Rate > 90 beats per minute

  • Body temperature < 36 or > 38°C

  • Tachypnea (high respiratory rate) > 20 breaths per minute or, on Blood Gas , a PaCO2 < 4.3 kPa (32 mm Hg)

  • White Blood Cell count < 4000 cells/mm³ or > 12000 cells/mm³ (< 4 x 109 or > 12 x 109 cells/L), or the presence of greater than 10% immature neutrophils.



DIFFERENCE BETWEEN SIRS AND SEPSIS

SIRS with a suspected or proven infection is called Sepsis .

Simply stated:
SIRS + infection = sepsis



COMPLICATIONS OF SIRS

SIRS can result in the Multiple Organ Dysfunction Syndrome .


CAUSES OF SIRS



RELATION TO CYTOKINE STORM

SIRS can be considered to be a subset of '' Cytokine Storm '', a general term (not commonly used in clinical medicine) for cytokine dysregulation.


SEE ALSO



REFERENCES



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