One of the important aspects of structural genomics is the emphasis on high throughput determination of protein structures. This is performed in dedicated Centers Of Structural Genomics .
While most structural biologists pursue structures of individual proteins or protein groups, specialists in Structural Genomics pursue structures of proteins on a genome wide scale. This implies large scale cloning, expression and purification. One main advantage of this approach is economy of scale. On the other hand, the scientific value of some resultant structures is at times questioned. An interesting Science article from January 2006 analyzes the structural genomics field .
