Information About

Peroxidase




Peroxidases (s. A majority of peroxidase protein sequences can be found in the PeroxiBase database. Peroxidases typically catalyze a reaction of the form:

:ROOR' + electron donor (2 e-) + 2H+ → ROH + R'OH

For many of these enzymes the optimal substrate is Hydrogen Peroxide , but others are more active with organic hydroperoxides such as lipid peroxides. Peroxidases can contain a Heme Cofactor in their active sites, or Redox-active Cysteine or Selenocysteine residues.

The nature of the Electron Donor is very dependent on the structure of the enzyme.
  • For example, Horseradish peroxidase can use a variety of organic compounds as electron donors and acceptors. Horseradish peroxidase has an accessible Active Site and many compounds can reach the site of the reaction.

  • For an enzyme such as Cytochrome C Peroxidase , the compounds that donate electrons are very specific, because there is a very closed active site.