Information AboutMyogenin |
| CATEGORIES ABOUT MYOGENIN | |
| gene expression | |
Myogenin is a basic-helix-loop-helix (bHLH) Transcription Factor expressed during the development, maintenance, and repair of Skeletal Muscle . Myogenin belongs to the MyoD family of BHLH transcription factors, which also include MyoD , Myf5 , and MRF4 . In particular, it is a Myogenic Regulatory Factor (MRF). When the DNA coding for myogenin was knocked out of the mouse Genome , severe skeletal muscle defects were observed. Mice lacking both copies of myogenin ( Homozygous -null) suffer from Perinatal lethality due to the lack of mature secondary skeletal muscle fibers throughout the body. Somite -( MyoD / Myf5 ) --> Myoblast -(myogenin/ MRF4 ) --> Myotube REFERENCES Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Hasty et al. Nature. 1993 Aug 5;364(6437):501-6. EXTERNAL LINKS |
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