| Mothers Against Decapentaplegic Homolog 9 |
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Information AboutMothers Against Decapentaplegic Homolog 9 |
| CATEGORIES ABOUT MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9 | |
| proteins | |
| developmental biology | |
| mh1 domain | |
| mh2 domain | |
| r-smad | |
SMAD9 or Mothers against decapentaplegic homolog 9 is a polypeptide that, as its name describes, is a homolog of the ". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members, SMAD9 is involved in Cell Signalling . When a Bone Morphogenetic Protein binds to a receptor (BMP type 1 receptor kinase) it causes SMAD9 to interact with SMAD Anchor For Receptor Activation (SARA).The binding of ligands causes the Phosphorylation of the SMAD9 protein and the dissociation from SARA and the association with SMAD4 . It is subsequently transferred to the Nucleus where it forms complexes with other proteins and acts as a Transcription Factor . SMAD9 is a Receptor Regulated SMAD ( R-SMAD ) and is activated by bone morphogenetic protein type 1 receptor kinase. There are two Isoforms of the protein. Confusingly, it is also sometimes referred to as SMAD8 in the literature.
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