Mothers Against Decapentaplegic Homolog 7 Article Index for
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Mothers Against Decapentaplegic Homolog 7
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  Name SMAD, Mothers against decapentaplegic homolog 7
  Photo SMURF2 SMAD7 complexpng
  Caption Solution Structure Of Smurf2 Ww3 Domain-Smad7 Py Peptide Complex
  Names '''Mothers against DPP homolog 7'''
  Symbol SMAD5
  AltSymbols hSMAD7, MADH7, MADH8, Smad7, SMAD7
  Chromosome 18
  Arm q
  Band 211
  Gene HUGO code: SMAD7
  Gene Type
  Type I-SMAD
  Functions Signal Transduction , Transcription
  Domains MH1 , MH2
  Diseases Scleroderma
  Taxa Phyla
  Cells ubiquitous high levels in Vascular Endothelium
  Location Primary:
  Mods Phosphorylation
  EntrezGene 4092
  HGNCid 6773
  OMIM 602932
  RefSeq NM_005904
  UniProt O15105


SMAD7 or Mothers against decapentaplegic homolog 7 is a polypeptide that, as its name describes, is a homolog of the ". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of ligands. Like many other TGFβ family members SMAD7 is involved in Cell Signalling . It is a TGFβ type 1 receptor Antagonist . It blocks TGFβ1 and activin associating with the receptor and blocking access to SMAD2 . It is an inhibitory SMAD ( I-SMAD ) and is enhanced by SMURF2 .