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Information About

Mothers Against Decapentaplegic Homolog 6




  Name SMAD, Mothers against decapentaplegic homolog 6
  Gene HUGO code: SMAD6
  Type I-SMAD (Inhibitory SMAD)
  Functions Signal Transduction , Transcription
  Domains MH1 , MH2
  Taxa '' Phyla
  Cells ubiquitous high levels in Lungs
  Location Primary:
  Mods Phosphorylation
  Names ''' SMAD 6, Mothers against DPP homolog 6, Smad6, hSMAD6'''


SMAD6 or '''mothers against decapentaplegic homolog 6''' is a polypeptide that, as its name describes, is a homolog of the Drosophila gene " Mothers Against Decapentaplegic ". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD6 is involved in Cell Signalling . It acts as a regulator of TGFβ family (such as Bone Morphogenetic Proteins ) activity by competing with SMAD4 and preventing the transcription of SMAD4 's gene products. There are two known isoforms of this protein.