| Mothers Against Decapentaplegic Homolog 5 |
Article Index for Mothers Against |
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Information AboutMothers Against Decapentaplegic Homolog 5 |
| CATEGORIES ABOUT MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5 | |
| proteins | |
| developmental biology | |
| mh1 domain | |
| mh2 domain | |
| r-smad | |
SMAD5 or Mothers against decapentaplegic homolog 5 is a polypeptide that, as its name describes, is a homolog of the ". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD5 is involved in Cell Signalling and modulates signals of Bone Morphogenetic Proteins (BMP's). The binding of ligands causes the Oligomerization and Phosphorylation of the SMAD5 protein. SMAD5 is a Receptor Regulated SMAD ( R-SMAD ) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGFβ is an inhibitor of Hematopoietic progenitor cells.
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