- Lewis , the largest island of the Western Isles of Scotland
;United States
- Second name:
- --- Blake Lewis (born 1981), Season six American Idol .
- --- C. S. Lewis (1898 - 1963), Northern Irish scholar and author of " The Chronicles Of Narnia "
- --- Carl Lewis , American track and field athlete
- --- Gilbert N. Lewis (1875 - 1946), American physical chemist
- --- Jerry Lewis , comedian, actor, director, philanthropist
- --- Lennox Lewis (born 1965), Olympic and World Champion boxer
- --- Lewis (surname) , surname
- --- Mercy Lewis , an accuser in the Salem Witch Trials
- --- Meriwether Lewis , an American explorer, soldier, and public administrator
- --- Morgan Lewis , an American songwriter
- --- Morgan Lewis , a Governor of New York State
- --- Paul Lewis (born 1843), British composer
- --- Rashard Lewis , American NBA player
- --- Wally Lewis (born 1959), an Australian rugby league footballer
- --- Warren K. Lewis (1882 - 1975), American chemical engineer
- First name:
- --- Lewis Carroll (1832 - 1898), pseudonym of Charles Dodgson, an English author, mathematician, logician, Anglican clergyman, and photographer
- --- Lewis Hamilton (born 1985), British Formula One driver
- '' Lewis (TV Series) '', British television detective series spin off of '' Inspector Morse ''
- Lewis, the son of a Mason in Freemasonry
- Lewis (cat) , a cat who garned national media attention after being placed under house arrest
- Lewis (Lifting Appliance) , steel lifting device used by Stonemasons to lift large stones into place with a crane, chain block or winch
- Lewis (robot) , robotic wedding photographer
- Lewis Acid , an acid
- Lewis Structure , a rationalisation of chemical bonding
- Lewis And Clark Expedition , the first United States overland expedition to the Pacific coast and back
- Lewis Gun , machine gun
- Lewis University , private school in Romeoville, Illinois
- Lewis (Mistreated) , A song written by " Radiohead " that is on the " My Iron Lung EP "
- Lewis (SSTI-1) , a NASA Satellite which failed soon after its launch on August 22, 1997
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