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THE ORIGIN OF THE TERM "PATIENT ZERO"

In the early years of the AIDS epidemic, there was a lot of controversy about a so-called ''Patient Zero,'' who was the basis of a complex ''transmission scenario'' compiled by Dr. William Darrow and colleagues at the Centers For Disease Control (CDC) in the US. This epidemiological study showed how 'Patient O' (for "Out of California" and mistakenly identified in the press as 'Patient Zero') had given HIV to multiple partners, who then in turn transmitted it to others and rapidly spread the virus to locations all over the world (Auerbach et al., 1984). In all, at least 40 of the 248 people diagnosed with AIDS by April 1982 were thought to have had sex either with him or with someone who had.

A journalist, Randy Shilts , subsequently wrote about Patient Zero—based on Darrow's findings—in his 1987 book '' And The Band Played On '', which identified Patient Zero as a gay Canadian Flight Attendant named Gaëtan Dugas ( February 20 , 1953March 30 , 1984 {Link without Title} ). For several years, Dugas was vilified as a "mass spreader" of HIV and the original source of the HIV epidemic among gay men. However, four years after the publication of Shilts's article, Dr. Darrow repudiated his study, admitting that its methods were flawed and claiming that Shilts had misrepresented the study's conclusions.


OTHER PATIENTS ZERO

  • Mary Mallon (a.k.a. Typhoid Mary) was a real Patient Zero. An apparently healthy carrier of typhoid, she infected 47 people while working as a cook. She eventually had to be quarantined to prevent her from spreading the disease to others.

  • The first recorded case of the Ebola virus was a 44-year-old schoolteacher named Mabalo Lokela, who died 8 September , 1976, 14 days after symptom onset.



PATIENTS ZERO IN FICTION

  • Patient Zero was a character in the Canadian film '' Zero Patience ''.

  • Patient Zero is the title of the first entry in a proposed series of bioterrorism thriller novels by Bram Stoker Award-winning author '' Jonathan Maberry '', featuring hero Joe Ledger, an agent of a sercret government organization called the Department of Military Science (DMS).

  • In the third '' Sliders '' episode, "Fever", Quinn's double is alleged to be Patient Zero of a global plague.

  • The movie '' Outbreak '' dealt with government officials charged with finding the index case of an outbreak of an Ebola -like virus .

  • Patient Zero was the name of a minor enemy in the computer game City Of Heroes .

  • In Max Brooks's '' World War Z '', a Chinese youth is patient zero for a worldwide zombie epidemic.

  • The 2006 television series '' Heroes '' features a super-powered man named Sylar who is described as "Patient Zero" of a genetic study into human evolution.

  • In the television show '' Numb3rs '', Patient Zero was a concept used to find the origin of the spread of the Spanish Flu virus.

  • Also in the television show '' The Outer Limits '', the term Patient Zero was used to a describe a person allegedly responsible for an epidemic.

  • Chuck Palahniuk's latest book, '' Rant (novel) '', is about a Patient Zero for rabies, called a superspreader.



SEE ALSO



REFERENCES

  • Auerbach DM, Darrow WW, Jaffe HW, Curran JW. (1984) Cluster of cases of the acquired immune deficiency syndrome. Patients linked by sexual contact. ''Am J Med.'' 76, 487-492 PMID 6608269



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