Information AboutHydrogenolysis |
| CATEGORIES ABOUT HYDROGENOLYSIS | |
| organic redox reactions | |
| hydrogen | |
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Hydrogenolysis is a catalytic Chemical Reaction whereby a molecule of hydrogen is added over a carbon-heteroatom single bond, effectively causing a "lysis" of the bond. The heteroatom may vary, but usually is oxygen, nitrogen or sulfur. A closely related reaction is Hydrogenation , where hydrogen is added over a carbon-carbon double bond (leading to the ultimate reduction to a single bond). A classic example of hydrogenolysis is debenzylation - the removal of a Benzyl Protecting Group usually attached to an oxygen or a nitrogen atom. With the current knowledge, the only definitive statement that can be made about the ease of hydrogenolysis is that presence of a positive charge (formal or partial) on the heteroatom greatly increases the rate of hydrogenolysis. A commercial large-scale example of hydrogenolysis is the Raney Nickel catalyzed "desulfurization" of substituted thiophene rings, which is a general method for the synthesis of certain hydrocarbons. The term was coined by Homer Burton Adkins . |
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