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Anemia due to
Hemolysis , the abnormal breakdown of
Red Blood Cell s either in the
Blood Vessel s (intravascular hemolysis) or elsewhere in the body (extravascular). It has numerous possible causes, ranging from relatively harmless to life-threatening. The general classification of hemolytic anemia is either acquired or inherited. Treatment depends on the cause and nature of the breakdown.
In a healthy person, a red blood cell survives 90 to 120 days (on average) in the circulation, so about 1% of human red blood cells break down each day. The
Spleen (part of the
Reticulo-endothelial System ) is the main organ which removes old and damaged RBCs from the circulation. In health the break down and removal of RBCs from the circulation is matched by the production of new RBCs in the
Bone Marrow .
When the rate of breakdown increases, the body compensates by producing more RBCs, but if compensation is inadequate clinical problems can appear. Breakdown of RBCs can exceed the rate that the body can make RBCs and so anemia can develop. The breakdown products of
Hemoglobin will accumulate in the blood causing
Jaundice and be excreted in the urine causing the urine to become dark brown in colour.
Signs of
Anemia are generally present (
Fatigue , later
Heart Failure ). Jaundice may be present.
- certain aspects of the medical history can suggest a cause for hemolysis (drugs, Fava Bean or other sensitivity, Prosthetic Heart Valve , or another medical illness)
- Peripheral Blood Smear microscopy:
- ---fragments of the red blood cells (" Schistocyte s") can be present
- ---some red blood cells may appear smaller and rounder than usual ( Spherocyte s)
- --- Reticulocytes are present in elevated numbers. This may be overlooked if a special Stain is not used.
- The level of Unconjugated Bilirubin in the blood is elevated. This may lead to Jaundice .
- The level of Lactate Dehydrogenase (LDH) in the blood is elevated
- Haptoglobin levels are decreased
- The direct Coombs Test is positive, if hemolysis is caused by an immune process.
- Haemosiderin in the urine indicates chronic intravascular haemolysis. There is also urobilinogen in the urine.
Clinical findings in haemolytic anaemias:
1. increased serum bilirubin levels in blood, therefore jaundice
2. pallor in mucous membrane and skin
3. increased urobilinogen in urine..urine turns dark on standing
4. Splenomegaly
5. Pigmented gallstones may be found
Causes of haemolytic anaemis can be either genetic or acquired.
Acquired haemolytic anaemia can be further divided into immune and non-immune mediated.
(direct
Coombs Test is positive)
(direct
Coombs Test is negative)
Drug induced hemolysis has large clinical relevance. It occurs when drugs actively provoke red cell destruction. Four mechanisms are described below.
Penicillin in high doses can induce immune mediated hemolysis via the
Hapten mechanism in which antibodies are targeted against the combination of penicillin in association with red blood cells. Complement is activated by the attached antibody leading to the removal of red blood cells by the spleen.
The drug itself can be targeted by the immune system, e.g. by IgE in a Type I hypersensitivity reaction to penicillin, rarely leading to anaphylaxis.
Non-immune drug induced hemolysis can occur via oxidative mechanisms. This is particularly likely to occur when there is an enzyme deficiency in the antioxidant defence system of the red blood cells. An example is where antimalarial oxidant drugs like primaquine damage red blood cells in
Glucose-6-phosphate Dehydrogenase Deficiency in which the red blood cells are more susceptible to oxidative stress due to reduced NADPH production consequent to the enzyme deficiency.
Some drugs cause RBC (red blood cell) lysis even in normal individuals. These include
Dapsone and
Sulfasalazine .
Non-immune drug-induced hemolysis can also arise from drug-induced damage to cell volume control mechanisms; for example drugs can directly or indirectly impair regulatory volume decrease mechanisms, which become activated during
Hypotonic RBC swelling to return the cell to a normal volume. The consequence of the drugs actions are irreversible cell swelling and lysis (e.g.
Ouabain at very high doses).
Definitive therapy depends on the cause.
- Symptomatic treatment can be given by Blood Transfusion , if there is marked anaemia.
- In severe immune-related hemolytic anemia, Steroid therapy is sometimes necessary.
- Sometimes Splenectomy can be helpful where extravascular heamolysis is predominant (ie most of the red blood cells are being removed by the spleen).
