Computational Biology

Computational biology is an interdisciplinary field that applies the techniques of Computer Science , Applied Mathematics , and Statistics to address problems inspired by Biology . Major fields in biology that use computational techniques include:

Bioinformatics , which applies Algorithm s and Statistical Techniques to biological datasets that typically consist of large numbers of DNA , RNA , or Protein sequences. Examples of specific techniques include Sequence Alignment , which is used for both sequence database searching and for comparison of Homologous sequences; Gene Finding ; and prediction of Gene Expression . (The term ''computational biology'' is sometimes used as a synonym for bioinformatics.)

Computational Biomodeling , a field within Biocybernetics concerned with building computational models of biological systems.

Computational Genomics , a field within Genomics which studies the Genome s of cells and organisms by high-throughput Genome Sequencing that requires extensive post-processing known as Genome Assembly , and which uses DNA Microarray technologies to perform statistical analyses on the genes expressed in individual cell types.

Molecular Modeling , a field dealing with theoretical methods and computational techniques to Model or mimic the behaviour of Molecule s, ranging from descriptions of a molecule of few atoms, to small chemical systems, to large biological molecules and material assemblies.

Systems Biology , which aims to model large-scale biological interaction networks (also known as the Interactome ), often using Differential Equation s.

Protein Structure Prediction and Structural Genomics , which attempt to systematically produce accurate structural models for three-dimensional Protein Structure s that have not been solved experimentally.

Computational Biochemistry and Biophysics , which make extensive use of structural modeling and simulation methods such as Molecular Dynamics and Monte Carlo -inspired Boltzmann Sampling methods in an attempt to elucidate the Kinetics and Thermodynamics of protein functions.

EXTERNAL LINKS

The First q-bio Conference on Cellular Information Processing - A conference in Santa Fe NM (Aug 8-11, 2007) focused on modeling of genetic regulatory and signal transduction systems and quantitatitve experimentation

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Computational Biology