Information AboutClock |
Circadian Locomotor Output Cycles Kaput, or '''Clock''' is a gene which encodes proteins regulating Circadian Rhythm . The CLOCK protein seems to affect both the persistence and length of the Circadian Cycle . CLOCK forms part of a Basic-helix-loop-helix Transcription Factor . BMAL-1 dimerizes with CLOCK ''in vivo'' and transactivates gene expression of Period and Timeless in Drosophila by binding to E-box elements in their promoters.Ishida N, Kaneko M, Allada R. " Biological clocks ". Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8819-20. PMID 10430850 BMAL1-CLOCK also regulates Cryptochrome genes (e.g. Cry1, Cry2) and Period genes (e.g. Per1, Per2, Per3) in mammals.Edery I. "Circadian rhythms in a nutshell". Physiol Genomics. 2000 Aug 9;3(2):59-74. PMID 11015601 The BMAL-CLOCK complex itself is regulated by the expression of Per and Cry genes. SEE ALSO REFERENCES EXTERNAL LINKS |
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