- C2c , a British train operating company
- Web Cam chat, from the instant messaging shorthand "cam-to-cam", usually spelt in lower case "c2c"
- Coast To Coast AM , a syndicated AM talk radio show
- Consumer-to-consumer Electronic Commerce
- Sea To Sea Cycle Route , the most popular of British cycle routes
- C2C (cable System) , a submarine telecommunications cable system linking east Asia and the USA
- Cadet Second Class, the rank of a cadet in his third (junior) year at the United States Air Force Academy
- "cover-to-cover"
- Close to the Customer Project: A marketing research collaboration between faculty and students as part of the Austin Entrepreneurship Program at Oregon State University. Through professional consultation and by conducting marketing research projects The C2C Project {Link without Title} assists the business community with market research problems.
- C2C Systems Ltd. , An Emil Lifecycle Management company
- 18C2C , a railroad operations and share trading board game.
- C2C (group) French DJ group, four-time winners of the DMC World Team DJ Championship
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