Information AboutAnticonvulsant |
| CATEGORIES ABOUT ANTICONVULSANT | |
| anticonvulsants | |
| epilepsy | |
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Many anticonvulsants block Sodium (Na+) Channels , Calcium (Ca2+) Channels , AMPA Receptor s or NMDA Receptor s. Some anticonvulsants inhibit the metabolism of GABA or increase its release. In the following list, the dates in parentheses are the earliest approved use of the drug. ALDEHYDES ''Main article: Aldehyde s''
AROMATIC ALLYLIC ALCOHOLS
BARBITURATES ''Main article: Barbiturate s'' Barbiturate s are Drugs that act as central nervous system (CNS) Depressant s, and by virtue of this they produce a wide spectrum of effects, from mild Sedation to Anesthesia . The following are Classified as anticonvulsants:
Phenobarbital was the main anticonvulsant from 1912 till the development of phenytoin in 1938. Today, phenobarbital is rarely used to treat epilepsy in new patients since there are other effective drugs that are less sedating. Phenobarbital sodium injection can be used to stop acute convulsions or Status Epilepticus , but a benzodiazepine such as lorazepam, diazepam or midazolam is usually tried first. Other barbiturates only have an anticonvulsant effect at anaesthetic doses. BENZODIAZEPINES ''Main article: Benzodiazepine s'' The benzodiazepines are a class of Drugs with Hypnotic , Anxiolytic , anticonvulsive, Amnestic and Muscle Relaxant properties. The relative strength of each of these properties in any given benzodiazepine varies greatly and influences the indications for which it is prescribed. Long-term use can be problematic due to the development of Tolerance and Dependency . Of the many drugs in this class, only a few are used to treat epilepsy:
The following benzodiazepines are used to treat Status Epilepticus :
BROMIDES ''Main article: Bromide s''
CARBAMATES ''Main article: Carbamate s''
CARBOXAMIDES ''Main article: Carboxamide s'' The following are carboxamides:
FATTY ACIDS ''Main article: Fatty Acid s'' The following are fatty-acids:
''Vigabatrin and progabide are also analogs of GABA.'' FRUCTOSE DERIVATIVES ''Main article: Fructose ''
GABA ANALOGS
HYDANTOINS ''Main article: Hydantoin s'' The following are hydantoins:
OXAZOLIDINEDIONES ''Main article: Oxazolidinedione s'' The following are oxazolidinediones:
PROPIONATES ''Main article: Propionate s'' PYRIMIDINEDIONES ''Main article: Pyrimidinedione s''
PYRROLIDINES ''Main article: Pyrrolidine s''
SUCCINIMIDES ''Main article: Succinimide s'' The following are succinimides:
SULFONAMIDES ''Main article: Sulfonamide s''
TRIAZINES ''Main article: Triazine s''
UREAS ''Main article: Urea s'' VALPROYLAMIDES (AMIDE DERIVATIVES OF VALPROATE) ''Main article: Amide s'' SEE ALSO REFERENCES EXTERNAL LINKS |
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