- OpenVMS and FreeVMS , a computer server operating system
- Variable-message Sign , an electronic traffic sign often used on highways
- Video Monitoring Services
- Visual Memory System , a storage device for the Sega Dreamcast console better known as a Visual Memory Unit (VMU)
- Vital Management Statistics , a performance-based metric system for productivity evaluation
- Voice Mail System
- Volcanogenic Massive Sulfide Ore Deposit s, a type of metal sulfide ore deposit
- Voucher Management System
- Voynich Manuscript , a mysterious illustrated book with incomprehensible contents
- Vehicle Management Systems
- Vendor Management System
- Vessel Monitoring System , a near real-time, usually satellite-based, positional tracking system for fishing vessels
- Virtual Modelling System
- Visual Measurement System
- Vitamins, Minerals & Supplements , products that provide extra nutrients like vitamin C.
- Voyage Management System , hardware and software that provide integrated, chart-based navigation for naval vessels
- Visual Management System , DVR Software & Hardware developer Glasgow www.vmsuk.com
- Vallivue Middle School , a middle school in the Vallivue School District .
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