Information AboutSyndecans |
| CATEGORIES ABOUT SYNDECANS | |
| proteoglycans | |
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FAMILY MEMBERS The syndecan protein family is comprised of four members. Syndecans 1 and 3 and syndecans 2 and 4 making up separate subfamilies having arisen by Gene duplication and divergent evolution from a single ancestoral gene.1 The syndecan numbers reflect the order in which the CDNA s for each family member were Cloned . All syndecans have an N-terminal Signal Peptide , an Ectodomain , a single Hydrophobic Transmembrane Domain , and a short C-terminal Cytoplasmic domain.2 The ectodomains show the least amount of Amino Acid sequence Conservation , no more than 10-20%, in contrast the transmembrane and cytoplasmic domains share around 60-70% amino acid sequence identity.3 The transmembrane domains contain an unusual alanine/glycine Sequence Motif while the cytoplasmic domain is essentially composed of two regions of Conserved Amino Acid Sequence (C1 and C2), separated by a central variable sequence of amino acids that is distinct for each family member (V). REFERENCES |
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