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Shock
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is a serious, often life-threatening
Medical condition where insufficient blood flow reaches the body
Tissues . As blood is the body's carrier of
Oxygen and
Nutrients , this leads to a deficiency of these essential inputs to life. The process affected, where blood enters the tissues, is called
Perfusion and this process not occurring properly causes a '''hypoperfusional''' (hypo = below) state.
Medical shock must not be confused with the by Michael L. Cheatham, MD, Ernest F.J. Block, MD, Howard G. Smith, MD, John T. Promes, MD, Surgical Critical Care Service, Department of Surgical Education,
Orlando Regional Medical Center Orlando , Florida
Shock can have a number of effects, all with similar outcomes, but all relate to a problem with the body's circulatory system. Key types of shock are:
- - A lack of blood in the normally closed circulatory system, usually caused by Bleeding . (Hypo=low, volaemic=volume of blood)
- - Inefficient pumping of the blood around the body (Cardio=heart)
- - A range of conditions which prevent the efficient distribution of blood, by dilating blood vessels, leading to a critical drop in blood pressure.
- - Another range of conditions where a physical object (such as a blood clot) stops blood from flowing around the body.
There are four stages of shock.
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; Initial : During this stage, the hypoperfusional state causes
Hypoxia , leading to the
Mitochondria being unable to produce
Adenosine Triphosphate . Due to this lack of oxygen, the
Cell Membranes become damaged and the cells perform
Anaerobic Respiration . This causes a build-up of
Lactic and
Pyruvic Acid which results in systemic
Metabolic Acidosis . The process of removing these compounds from the cells by the
Liver requires oxygen, which is absent.
; Compensatory : This stage is characterised by the body employing physiological mechanisms, including neural, hormonal and bio-chemical mechanisms in an attempt to reverse the condition. As a result of the
Acidosis , the person will begin to
Hyperventilate in order to rid the body of carbon dioxide (CO
2). CO
2 indirectly acts to acidify the blood and by removing it the body is attempting to raise the pH of the blood. The
Baroreceptors in the
Arteries detect the resulting
Hypotension , and cause the release of
Adrenaline and
Noradrenaline . Noradrenaline causes predominately
Vasoconstriction with a mild increase in
Heart Rate , whereas
Adrenaline predominately causes an increase in
Heart Rate with a small effect on the
Vascular tone; the combined effect results in an increase in
Blood Pressure .
Renin -
Angiotensin axis is activated and
Arginine Vasopressin is released to conserve fluid via the kidneys. Also, these hormones cause the vasoconstriction of the
Kidneys ,
Gastrointestinal Tract , and other organs to divert blood to the heart,
Lungs and
Brain . The lack of blood to the
Renal system causes the characteristic low
Urine production. However the effects of the
Renin -
Angiotensin axis take time and are of little importance to the immediate
Homeostatic mediation of shock.
; Progressive : Should the cause of the crisis not be successfully treated, the shock will proceed to the progressive stage and the compensatory mechanisms begin to fail. Due to the decreased perfusion of the cells,
Sodium ions build up within while
Potassium ions leak out. As anaerobic metabolism continues, increasing the body's metabolic acidosis, the arteriolar and precapillary
Sphincters constrict such that blood remains in the
Capillaries . Due to this, the hydrostatic pressure will increase and, combined with
Histamine release, this will lead to leakage of fluid and
Protein into the surrounding tissues. As this fluid is lost, the blood concentration and
Viscosity increase, causing sludging of the micro-circulation. The prolonged vasoconstriction will also cause the vital organs to be compromised due to reduced perfusion.
; Refractory : At this stage, the vital organs have failed and the shock can no longer be reversed.
Brain Damage and cell death have occurred. Death will occur imminently.
Shock is a complex and continuous condition and there is no sudden transition from one stage to the next.
In 1972 Hinshaw and Cox suggested the following classification which is still used today. It uses four types of shock: hypovolaemic, cardiogenic, distributive and obstructive shock:
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- - This is the most common type of shock and based on insufficient circulating volume. Its primary cause is loss of fluid from the Circulation from either an internal or external source. An internal source may be Haemorrhage . External causes may include extensive bleeding, high output Fistulae or severe Burn s.
- - This type of shock is caused by the failure of the heart to pump effectively. This can be due to damage to the heart muscle, most often from a large Myocardial Infarction . Other causes of cardiogenic shock include Arrhythmia s, Cardiomyopathy , Congestive Heart Failure (CHF), Contusio Cordis or Cardiac Valve problems.
- - As in hypovolaemic shock there is an insufficient intravascular volume of blood. This form of "relative" hypovolaemia is the result of dilation of blood vessels which diminishes Systemic Vascular Resistance . Examples of this form of shock are:
- --- Septic Shock - This is caused by an overwhelming infection leading to Vasodilation , such as by Gram Negative bacteria i.e. '' Escherichia Coli '', Proteus species, '' Klebsiella Pneumoniae '' which release an Endotoxin which produces adverse biochemical, immunological and occasionally neurological effects which are harmful to the body. Gram-positive cocci, such as Pneumococci and Streptococci , and certain fungi as well as Gram-positive bacterial toxins produce a similar syndrome.
- --- Anaphylactic Shock - Caused by a severe Anaphylactic Reaction to an Allergen , Antigen , Drug or foreign protein causing the release of Histamine which causes widespread vasodilation, leading to hypotension and increased capillary permeability.
- --- Neurogenic Shock - Neurogenic shock is the rarest form of shock. It is caused by Trauma to the Spinal Cord resulting in the sudden loss of Autonomic and Motor reflexes below the injury level. Without stimulation by Sympathetic Nervous System the vessel walls relax uncontrolled, resulting in a sudden decrease in Peripheral Vascular Resistance , leading to Vasodilation and Hypotension .
- - In this situation the flow of blood is obstructed which impedes circulation and can result in Circulatory Arrest . Several conditions result in this form of shock.
- --- Cardiac Tamponade in which blood in the pericardium prevents inflow of blood into the heart (venous return). Constrictive Pericarditis , in which the Pericardium shrinks and hardens, is similar in presentation.
- --- Tension Pneumothorax . Through increased intrathoracic pressure, bloodflow to the heart is prevented (venous return).
- ---Massive Pulmonary Embolism is the result of a thromboembolic incident in the bloodvessels of the Lung s and hinders the return of blood to the heart.
- --- Aortic Stenosis hinders circulation by obstructing the Ventricular Outflow Tract
Recently a fifth form of shock has been introduced:
- based on Endocrine disturbances.
- --- Hypothyroidism , in critically ill patients, reduces Cardiac Output and can lead to hypotension and respiratory insufficiency.
- --- Thyrotoxycosis may induce a reversible cardiomyopathy.
- ---Acute Adrenal Insufficiency is frequently the result of discontinuing Corticosteroid treatment without tapering the dosage. However, surgery and intercurrent disease in patients on corticosteroid therapy without adjusting the dosage to accommodate for increased requirements may also result in this condition.
- ---Relative adrenal insufficiency in critically ill patients where present Hormone Levels are insufficient to meet the higher demands
- ---Anxiety, restlessness, Altered Mental State due to decreased cerebral perfusion and subsequent hypoxia.
- ---Hypotension due to decrease in circulatory volume.
- ---A rapid, weak, thready pulse due to decreased blood flow combined with tachycardia.
- ---Cool, clammy skin due to vasoconstriction and stimulation of vasoconstriction.
- ---Rapid and deep respirations due to sympathetic nervous system stimulation and acidosis.
- ---Hypothermia due to decreased perfusion and evaporation of sweat.
- ---Thirst and dry mouth, due to fluid depletion.
- ---Fatigue due to inadequate oxygenation.
- ---Cold and mottled skin ( Cutis Marmorata ), especially extremities, due to insufficient perfusion of the skin.
- , similar to hypovolaemic shock but in addition:
- ---Distended Jugular Vein s due to increased Jugular Venous Pressure .
- ---Absent pulse due to tachy Arrhythmia .
- , similar to hypovolaemic shock but in addition:
- ---Distended Jugular Vein s due to increased jugular venous pressure.
- --- Pulsus Paradoxus in case of tamponade
- , similar to hypovolaemic shock except in the first stages:
- ---Pyrexia and fever, or Hyperthermia , due to overwhelming bacterial infection.
- ---Vasodilation and increased Cardiac Output due to Sepsis .
- , similar to hypovolaemic shock except in the skin's characteristics. In neurogenic shock, the skin is warm and dry.
- ---Skin eruptions and large welts.
- ---Localised Edema , especially around the face.
- ---Weak and rapid pulse.
- ---Breathlessness and cough due to Narrowing Of Airways and Swelling Of The Throat .
In the early stages, shock requires immediate intervention to preserve life. Therefore, the early recognition and treatment depends on the transfer to a hospital.
The management of shock requires immediate intervention, even before a diagnosis is made. Re-establishing perfusion to the organs is the primary goal through restoring and maintaining the blood circulating volume ensuring oxygenation and blood pressure are adequate, achieving and maintaining effective cardiac function, and preventing complications. Patients attending with the symptoms of shock will have, regardless of the type of shock, their airway managed and oxygen therapy initiated. In case of
Respiratory Insufficiency (i.e.
Diminished Levels Of Consciousness ,
Hyperventilation due to
Acid-base disturbances or
Pneumonia )
Intubation and
Mechanical Ventilation may be necessary. A
Paramedic may intubate in emergencies outside the hospital, whereas a patient with respiratory insufficiency in-hospital will be intubated usually by a
Physician .
The aim of these acts is to ensure survival during the transportation to the hospital; they do not cure the cause of the shock. Specific treatment depends on the cause.
A compromise must be found between:
- raising the blood pressure to be able to transport "safely" (when the blood pressure is too low, any motion can lower the heart and brain perfusion, and thus cause death);
- respecting the Golden Hour . If surgery is required, it should be performed within the first hour to maximise the patient's chance of survival.
This is the ''stay and play'' versus the ''load and go'' debate.
In
Hypovolaemic Shock , caused by bleeding, it is necessary to immediately control the
Bleeding and restore the victim's blood volume by giving infusions of balanced salt solutions.
Blood Transfusion s are necessary for loss of large amounts of blood (e.g. greater than 20% of blood volume), but can be avoided in smaller and slower losses.
Hypovolaemia due to burns, diarrhoea, vomiting, etc. is treated with infusions of electrolyte solutions that balance the nature of the fluid lost. Sodium is essential to keep the fluid infused in the extracellular and intravascular space whilst preventing water intoxication and brain swelling.
Metabolic Acidosis (mainly due to lactic acid) accumulates as a result of poor delivery of oxygen to the tissues, and mirrors the severity of the shock. It is best treated by rapidly restoring intravascular volume and perfusion as above. Inotropic and vasoconstrictive drugs should be avoided, as they may interfere in knowing blood volume has returned to normal.
Regardless of the cause, the restoration of the circulating volume is priority. As soon as the airway is maintained and oxygen administered the next step is to commence replacement of fluids via the intravenous route.
Opinion varies on the type of fluid used in shock. The most common are:
- Crystalloids - Such as sodium chloride (0.9%), or Hartmann's solution (Ringer's lactate). Dextrose solutions which contain free water are less effective at re-establishing circulating volume, and promote hyperglycaemia.
- Colloids - For example, synthetic albumin (Dextran™), polygeline (Haemaccel™), succunylated gelatin (Gelofusine™) and hetastarch (Hepsan™). Colloids are, in general, much more expensive than crystalloid solutions and have not conclusively been shown to be of any benefit in the initial treatment of shock.
- Combination - Some clinicians argue that individually, colloids and crystalloids can further exacerbate the problem and suggest the combination of crystalloid and colloid solutions.
- Blood - Essential in severe haemorrhagic shock, often pre-warmed and rapidly infused.
Vasoconstrictor agents have no role in the initial treatment of hemorrhagic shock, due to their relative inefficacy in the setting of acidosis, and due to the fact that the body, in the setting of hemorrhagic shock, is in an endogenously catecholaminergic state. Definitive care and control of the hemorrhage is absolutely necessary, and should not be delayed.
In . Inotropic agents, which enhance the heart's pumping capabilities, are used to improve the contractility and correct the hypotension. Should that not suffice an
Intra-aortic Balloon Pump -which reduces
Workload for the heart, and improves perfusion of the
Coronary Arteries - can be considered or a left
Ventricular Assist Device -which augments the pump-function of the heart.
The main goals of the treatment of cardiogenic shock are the re-establishment of circulation to the myocardium, minimising heart muscle damage and improving the heart's effectiveness as a pump. This is most often performed by percutaneous coronary intervention and insertion of a stent in the culprit coronary lesion or sometimes by cardiac bypass.
Although this is a protection reaction, the shock itself will induce problems; the circulatory system being less efficient, the body gets "exhausted" and finally, the blood circulation and the breathing slow down and finally stop (
Cardiac Arrest ). The main way to avoid this deadly consequence is to make the blood pressure rise again with
- fluid replacement with Intravenous Infusion s;
- use of vasopressing drugs (e.g. to induce Vasoconstriction );
- use of Anti-shock Trousers that compress the legs and concentrate the blood in the vital organs (lungs, heart, brain).
- use of blankets to keep the patient warm - metallic PET Film emergency blankets are used to reflect the patient's body heat back to the patient.
In
Distributive Shock caused by sepsis the infection is treated with
Antibiotic s and supportive care is given (i.e.
Inotropica ,
Mechanical Ventilation ,
Renal Function Replacement ).
Anaphylaxis is treated with
Adrenaline to stimulate cardiac performance and
Corticosteroid s to reduce the
Inflammatory Response . In
Neurogenic Shock because of vasodilation in the legs, one of the most suggested treatments is placing the patient in the Trendelenburg position, thereby elevating the legs and shunting blood back from the periphery to the body's core. However, since bloodvessels are highly compliant, and expand as result of the increased volume locally, this technique does not work. More suitable would be the use of
Vasopressors .
In
Obstructive Shock , the only therapy consists of removing the obstruction.
Pneumothorax or
Haemothorax is treated by inserting a
Chest Tube , pulmonary embolism requires
Thrombolysis (to reduce the size of the clot), or
Embolectomy (removal of the
Thrombus ), tamponade is treated by draining fluid from the
Pericard ial space through
Pericardiocentesis .
In
Endocrine Shock the hormone disturbances are corrected.
Hypothyroidism requires supplementation by means of
Levothyroxine , in
Hyperthyroidism the production of hormone by the
Thyroid is inhibited through
Thyreostatic a, i.e.
Methimazole (Tapazole®) or PTU (
Propylthiouracil ). Adrenal insufficiency is treated by supplementing corticosteroids.
The prognosis of shock depends on the underlying cause and the nature and extent of concurrent problems. Hypovolemic, anaphylactic and neurogenic shock are readily treatable and respond well to medical therapy. Septic shock however, is a grave condition and with a mortality rate between 30% and 50%. The prognosis of cardiogenic shock is even worse.
Shock is said to evolve from ''reversible'' to ''irreversible'' in experimental hemorrhagic shock involving certain animal species (dogs, rats, mice) that develop intense vasoconstriction of the gut. Death is due to hemorrhagic necrosis of the intestinal lining when shed blood in reinfused. In pigs and humans 1) this is not seen and cessation of bleeding and restoration of blood volume is usually very effective; however 2) prolonged hypovolemia and hypotension does carry a risk of respiratory and then cardiac arrest. Perfusion of the brain may be the greatest danger during shock. Therefore urgent treatment (cessation of bleeding, rapid restoration of circulating blood volume and ready respiratory support) is essential for a good prognosis in hypovolemic shock.
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- Ledingham, I.M. and Ramsey, G. (1986) "Shock". ''British Journal of Anaesthesia'' Vol. 58, pp. 169-189.
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