;Computers and technology
- Short Message Service , a form of text messaging on mobile phones
- Super Media Solution , Rahyab's new model of merging all communication method like Email, Mobile, wired-line, SMS, Weblog altogether in one numeric website.
- Scalable Modeling System , a directive-based parallel programming tool developed by the NOAA to solve problems defined on structured grid (for example Weather Forecasting )
- Single-molecule Spectroscopy , a technique for imaging one molecule (see also Single-molecule Experiment and Spectroscopy )
- SMS/800 or 800 Service Management System, for administration of toll-free phone numbers in North America
- IBM Standard Modular System , a system of standard transistorised circuit boards developed by IBM in the late 1950s
- STING Millennium Suite, a bioinformatics software
- Spectral Modeling Synthesis , an approach in Audio Synthesis , referred to as "Sines + Noise".
- Sudden Motion Sensor , a patented feature of Apple Computer's notebook computers
- System Management Services , firmware code for the IBM System P machines
- Microsoft Systems Management Server , Microsoft product to manage remotely Microsoft-based computer systems
;Science, mathematics, and medicine
;Entertainment and art
;Companies and organizations
;Other meanings
- Safety Management System , any written system including programs, policies, procedures and other documentation to manage how the business of safety is managed and conducted for an organization
- ''Seiner Majestät Schiff'' , an abbreviation for "His Majesty's Ship" in the German Kaiserliche Marine and the Austro-Hungarian Navy
- Skolt Sami , ISO 639 alpha-3 language code
- ''Sonar Middleware Standard'', a publication of the Naval Undersea Warfare Center
- State Management Scheme , nationalisation of the pubs in parts of the UK
- '' Supermoto '' Sole, a SIDI marketing designation for motorcycle footwear design
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