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SMAD, Mothers against decapentaplegic homolog 2
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HUGO code: SMAD2
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R-SMAD
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Signal Transduction , Transcription
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MH1 , MH2
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Colorectal Carcinoma
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many Metazoan Phyla
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Skeleton , Heart , Placenta , Ovary , Tooth , Pancreas , Prostate
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Primary:
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Phosphorylation
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''' SMAD 2, Mothers against DPP homolog 2, Mad-related protein 2, hMAD-2, JV18-1, hSMAD2'''
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is a polypeptide that, as its name describes, is a homolog of the ". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD2 is involved in Cell Signalling . SMAD2 modulates signals of Activin and TGFβ's. It interacts with SMAD Anchor For Receptor Activation (SARA).The binding of ligands causes the Phosphorylation of the SMAD2 protein and the dissociation from SARA and the association with SMAD4 . It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a Transcription Factor . SMAD2 is a Receptor Regulated SMAD ( R-SMAD ) and is activated by bone morphogenetic protein type 1 receptor kinase.
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