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Roundup is the brand name of a systemic, broad-spectrum of all time. In the US 5-8 million pounds are used every year on lawns and yards and 85-90 million pounds are used annually in US agriculture. Monsanto developed and Patent ed the glyphosate molecule in the 1970s , and marketed Roundup from 1973. It retained exclusive rights in the US until its US patent expired in September, 2000, and maintained a predominant marketshare in countries where the patent expired earlier. The Active Ingredient of Roundup is the Isopropylamine Salt of glyphosate. Glyphosate's mode of action is to inhibit an Enzyme involved in the synthesis of the Amino Acid s Tyrosine , Tryptophan and Phenylalanine . It is absorbed through foliage and translocated to growing points. Weeds and grass will generally re-emerge within one to two months after usage. Because of this mode of action, it is only effective on actively growing plants; it is not effective as a Pre-emergence Herbicide . Monsanto also produces seeds which grow into plants Genetically Engineered to be tolerant to glyphosate which are known as '' Roundup Ready '' crops. The genes contained in these seeds are patented. Such crops allow farmers to use glyphosate as a post-emergence pesticide against both broadleaf and cereal weeds. Soy was the first ''Roundup Ready'' crop and was produced at Monsanto's Agracetus Campus located in Middleton, Wisconsin. Current ''Roundup Ready'' crops include Maize (corn), Sorghum , Cotton , Soy , Canola and Alfalfa . In May 2007, a federal court decision barred new plantings of Roundup Ready alfalfa and the resale of seeds, due to the failure of regulators to complete an Environmental Impact Statement examining the potential that genetically-modified alfalfa would contaminate non-GM alfalfa crops, encourage new weeds tolerant to herbicides and limit export markets. The largest single user of Roundup reportedly is the U.S. Government , which sprays huge quantities of the herbicide over the northern countries of South America in an effort to discourage cultivation of the Coca plant. (See article '' Plan Colombia ''). CHEMISTRY Glyphosate is an aminophosphonic analogue of the natural amino acid for Applied Chemistry.Colby Stong, The Scientist 1990, 4(10):28 {Link without Title} BIOCHEMISTRY Glyphosate kills plants by inhibiting the pathway is not present in animals, which obtain aromatic amino acids from their diet. Glyphosate has also been shown to inhibit other plant enzymes(Su , L.Y. et al. 1992. The relationship of glyphosate treatment to sugar metabolism in sugarcane: New physiological insights. J. Plant Physiol. 140:168-173.)(Lamb, D.C. et al. 1998. Glyphosate is an inhibitor of plant cytochrome P450: Functional expression of Thlaspi arvensae cytochrome P45071B1/ reductase fusion protein in Escherichia coli. Biochem. Biophys. Res. Comm. 244:110114.) and also has been found to affect animal enzymes.(Hietanen, E., K. Linnainmaa, and H. Vainio. 1983. Effects of phenoxy herbicides and glyphosate on the hepatic and intestinal biotransformation activities in the rat. Acta Pharma. et Toxicol. 53:103-112.) HEALTH, ECOLOGICAL CONCERNS AND CONTROVERSY Toxicity and ecological impact Glyphosate is classed as a moderately toxic Herbicide and in EPA toxicity class III. A 2000 review of the available literature concluded that "under present and expected conditions of new use, there is no potential for Roundup herbicide to pose a health risk to humans".Williams GM, Kroes R, Munro IC. (2000) Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans. ''Regulatory Toxicology and Pharmacology'', 31 (2): 117-165. PMID 10854122. The Northwest Coalition for Alternatives to Pesticides disputes this classification.Carolyn Cox, Northwest Coalition for Alternatives to Pesticides {Link without Title} Scientific fraud and false advertising On two occasions the American EPA has caught scientists deliberately falsifying test results at research laboratories hired by Monsanto to study glyphosate.(US EPA Communications and Public Affairs 1991 ''Note to correspondents'' Washington DC Mar 1)(US EPA Communications and Public Affairs 1991 Press Advisory. ''EPA lists crops associated with pesticides for which residue and environmental fate studies were allegedly manipulated''. Washington DC Mar 29)(U.S. Congress. House of Representatives. Com. on Gov. Oper. 1984. ''Problems palgue the EPA pesticide registration activities''. House Report 98-1147) In the first incident involving "Industrial Biotest Laboratories", a reviewer stated after finding "routine falsification of data" that it was "hard to believe the scientific integrity of the studies when they said they took specimens of the Uterus from male rabbits".(U.S. EPA 1978 Data validation. Memo from K LOcke, Toxicology Branch, to R Taylor, Registration Branch. Washington DC Aug 9)(U.S. EPA Office of pesticides and Toxic Substances 1983, ''Summary of the IBT review program''. Washington D.C. July)Schneider, K. 1983. Faking it: The case against Industrial Bio-Test Laboratories. The Amicus Journal (Spring):14-26. Reproduced at Planetwaves In the second incident of falsifying test results in 1991, the owner of the lab (Craven Labs), and three employees were indicted on 20 felony counts, the owner was sentenced to 5 years in prison and fined 50,000 dollars, the lab was fined 15.5 million dollars and ordered to pay 3.7 million in restitution.(US Dept. of Justice. United States Attorney. Western District of Texas 1992. ''Texas laboratory, its president, 3 employees indicted on 20 felony counts in connection with pesticide testing''. Austin TX Sept 29) (US EPA Communications, Education, And Public Affairs 1994 Press Advisory. ''Craven Laboratories, owner, and 14 employees sentenced for falsifying pesticide tests''. Washington DC Mar 4) Craven laboratories performed studies for 262 pesticide companies including Monsanto. Monsanto has been accused of false and misleading advertising of glyphosate products, prompting a law suit by the New York State attorney general.[http://www.mindfully.org/Pesticide/Monsanto-v-AGNYnov96.htm Monsanto has also been accused of the false advertising of roundup in Europe where it is currently appealing a law suit on the issue.http://www.organicconsumers.org/articles/article_4114.cfm] Human and mammalian toxicity Outside its intended use, glyphosate can be lethal. For example, with intentional poisonings (e.g. Suicide ), there is approximately a 10% mortality for those ingesting Roundup, compared to 70% for those ingesting Paraquat .Nagami et al. (2005). Hospital-based survey of pesticide poisoning in Japan, 1998--2002. ''Int J Occup Environ Health'', 11(2):180-4.PMID 15875894 A review of the toxicological data on Roundup shows that there are at least 58 studies of the effects of Roundup itself on a range of organisms.JP Giesy, KR Solomon, S Dobson (2000). "Ecotoxicological Risk Assessment for Roundup Herbicide". Reviews of Environmental Contamination and Toxicology 167: 35-120 This review concluded that ''"for terrestrial uses of Roundup minimal acute and chronic risk was predicted for potentially exposed nontarget organisms"''. It also concluded that there were some risks to aquatic organisms exposed to Roundup in shallow water. More recent research indicates glyphosate induces a variety of functional abnormalities in fetuses and pregnant rats. Also in recent mammalian research, glyphosate has been found to interfere with an enzyme involved testosterone production in mouse cell cultureWalsh ''et al'' Roundup inhibits steroidogenesis by disrupting steroidogenic acute regulatory (StAR) protein expression. Environ Health Perspect. 2000 108: 769–776.[http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=10964798 and to interfere with an estrogen biosynthesis enzyme in cultures of Human Placental cells.Richard et al, Differential Effects of Glyphosate and Roundup on Human Placental Cells and Aromatase, Environmental Health Perspectives Vol. 113, No.6, 716-720[http://www.ehponline.org/members/2005/7728/7728.pdf] In controlled residue studies the WHO found "significant residues" on wheat with residues not lost during baking.WHO Environmental health criteria # 159 {Link without Title} Concerns have been raised abouts Roundup's effect on flora, mammals and birds brought about through Habitat destruction. {Link without Title} The have all concluded that pure glyphosate is not carcinogenic. Opponents of glyphosate claim that Roundup has been found to cause genetic damage, citing Peluso et al.Peluso M, Munnia A, Bolognesi C, Parodi S. Environ Mol Mutagen. 1998 31:55-9 PMID 9464316 The authors concluded that the damage was "''not related to the active ingredient, but to another component of the herbicide mixture''. Aquatic effects Fish and aquatic Invertebrates are more sensitive to roundup than terrestrial organisms. Glyphosate is generally less persistent in water than in soil, with 12 to 60 day persistence observed in Canadian pond water, yet persistence of over a year have been observed in the sediments of ponds in Michigan and Oregon. Roundup is not registered for aquatic usesMonsanto Backgrounder 2005 Response to "The impact of insecticides and herbicides on the biodiversity and productivity of aquatic communities" and studies of its effects on amphibians indicates it is toxic to them.Rick A. Relyea 2005 The impact of insecticides and herbicides on the biodiversity and productivity of aquatic communities Ecological Applications 15:618–627 Glyphosate formulations that are registered for aquatic use have been found to have negligible adverse effects on sensitive amphibians.Wojtaszek et al Effects of vision herbicide on mortality, avoidance response, and growth of amphibian larvae in two forest wetlands Environmental Toxicology and Chemistry 23:832–842 2004 [http://www.whitemoose.ca/Forestry/AmphibiansPDF-Tembec.pdf Environmental degradation and effects When glyphosate comes into contact with the soil it can be rapidly bound to soil particles and be inactivated.US EPA Reregistration Eligibility Decision - Glyphosate - (EPA-738-F-93-011) 1993 Unbound glyphosate can be degraded by bacteria.Balthazor, Terry M and Laurence Hallas (1986) Glyphosate-degrading microorganisms in industrial waste treatment biosystems. Appl. Environ. Microbiol. 51:432-34.[http://aem.asm.org/cgi/reprint/51/2/432.pdf Low activity because of binding to soil particles suggests that glyphosate's effects on Soil Flora will be limited. Low glyphosate concentrations can be found in many creeks and rivers in U.S. and Europe, and in the US glyphosate has been called "relatively persistent" by its EPA. In soils, half lives vary from as little as 3 days at a site in Texas, 141 days at a site in Iowa, to between 1 - 3 years in Swedish forest soils. {Link without Title} It appears that more northern sites have the longest soil persistences such as in Canada and Scandinavia. However, the binding of glyphosate to particulates can be an advantage. Treatment of industrial wastewater using immobilized bacteria showed complete conversion of glyphosate to nontoxic aminomethylphosphonic acid.Adams, William, Laurence Hallas , and Michael Heitkamp. 1994. Microbes and their use to degrade N-phosphonomethylglycine in waste streams. United States Patent 5288635 {Link without Title} The US EPA concluded that many endangered species of plants, as well as the Houston toad, may be at risk from glyphosate use. One study has shown an effect on growth and survival of earthworms.(Springett & Gray 1992, ''Soil Biol. Biochem''. 24 (12):1739-1744) {Link without Title} The results of this study are in conflict with other data and has been criticized on methodological grounds.JP Giesy, KR Solomon, S Dobson (2000). "Ecotoxicological Risk Assessment for Roundup Herbicide". Reviews of Environmental Contamination and Toxicology 167: 35-120 In other studies nitrogen fixing bacteria have been impaired, and also crop plant susceptibility to disease has been increased.(Santos & Flores 1995, ''Lett. Appl.'' Microbiol. 20:349-352)(Brammel & Higgins 1988, ''Can. J. Bot'' 66:1547-1555)(Johal & Rahe 1988, Molec. Plant Pathol. 32:267-281)(Mekwatanakarn & Sivassithamparam 1987, ''Biol. Fertil. Soils'' 5:175-180)(Kawate et al. 1997, ''Weed Sci''. 45:739-743)(Bergvinson & Borden 1992, ''Can J. For. Res''. 22:206-209) Monsanto firmly denies any negative impact on anything, including wildlife, and has many studies it has funded to back up its position. They would also be quick to point out that any possible negative impact on earthworms and nitrogen fixing bacteria, etc., would be offset by greater yields as of the elimination of weeds, and also would point to soil benefits from less mechanical cultivation of weeds by using Roundup and similar products. REPRODUCTIVE HEALTH CONCERNS AND EDC ACTIVITY There are concerns about the effects of glyphosate (and Roundup) on possible human reproductive dysfunction. Endocrine disruptor debate In-vitro studies have shown glyphosate to have an effect on progesterone production in mammalian cells and can affect mortality of placental cells in-vitro. Whether these studies classify glyphosate as an Endocrine Disruptor is a matter of debate. Some feel that in-vitro studies are insufficient, and are waiting to see if animal studies show a change in endocrine activity, since a change in a single cell line may not occur in an entire organism. Additionally, current in-vitro studies expose cell lines to concentrations orders of magnitude greater than would be found in real conditions, and through pathways that would not be experienced in real organism. Others feel that in-vitro studies, particularly ones identifying not only an effect, but a chemical pathway, are sufficient evidence to classify glyphosate as an endocrine disruptor, on the basis that even small changes in endocrine activity can have lasting effects on an entire organism that may be difficult to detect through whole organism studies alone. Further research on the topic has been planned. GLYPHOSATE RESISTANCE IN WEEDS AND MICROORGANISMS The first documented cases of weed resistance to glyphosate were found in Australia, involving rigid ryegrass near Orange, New South Wales. Some farmers in the United States have expressed concern that weeds are now developing with glyphosate resistance, with 13 states now reporting resistance, and this poses a problem to many farmers, including cotton farmers, that are now heavily dependent on glyphosate to control weeds.[http://southeastfarmpress.com/news/021006-Glyphosate-resistance/ Farmers associations are now reporting 103 biotypes of weeds within 63 weed species with herbicide resistance, and this will continue to grow as a problem.[http://southeastfarmpress.com/news/021006-Glyphosate-resistance/ [http://www.newfarm.com/news/2004/0804/083104/weeds.shtml] Some and inserted into soybeans. The CP4 EPSPS gene was engineered for Plant Expression by Fusing the 5' end of the gene to a Chloroplast Transit Peptide derived from the Petunia EPSPS. This transit peptide was used because it had shown previously an ability to deliver bacterial EPSPS to the chloroplasts of other plants. The Plasmid used to move the gene into soybeans was PV-GMGTO4. It contained three bacterial genes, two PC4 EPSPS genes, and a gene Encoding Beta-glucuronidase ( GUS ) from '' Escherichia Coli '' as a marker. The DNA was injected into the soybeans using the Particle Acceleration Method . Soybean cultivar A54O3 was used for the Transformation . The Expression of the GUS gene was used as the initial evidence of transformation. GUS expression was detected by a staining method in which the GUS enzyme converts a Substrate into a blue Precipitate . Those plants that showed GUS expression were then taken and sprayed with glyphosate and their tolerance was tested over many generations. GENETICALLY MODIFIED CROPS In s in soybean fields since glyphosate could be sprayed on fields without hurting the crop. As of 2005, 87% of U.S. soybean fields were planted to glyphosate resistant varieties.USDA/APHIS Environmental Assessment - In response to Monsanto Petition 06-178-01p seeking a Determination of Non-regulated Status for + Roundup RReady2Yield Soybean MON 89788, OECD Unique Identifier MON-89788-1, U.S. Department of Agriculture Animal and Plant Health Inspection Service + Biotechnology Regulatory Services page 13 {Link without Title} National Agriculture Statistics Service (2005) in Acreage eds. Johanns, M. & Wiyatt, S. D. 6 30, (U.S. Dept. of Agriculture, Washington, DC). + TRADENAMES It was first sold by Monsanto under the tradename Roundup, but the name is no longer under Patent . It continues to be marketed under various names (for example TOP UP48 in Thailand ). OTHER USES Glyphosate is one of a number of herbicides used by the United States government to spray Colombia n Coca fields through Plan Colombia . Its health effects, effects on legal crops, and effectiveness in fighting the War On Drugs have been widely disputed. Widespread application of glyphosate in attempts to destroy coca crops in South America have resulted in the development of glyphosate-resistant strains of coca which have been Selectively Bred to be both "Roundup ready" and also larger and higher yielding than the original strains of the plant. {Link without Title} New Super Strain of Coca Plant Stuns Anti-Drug Officials. Jeremy McDermott. The Scotsman (Scotland) 27 August 2004 EXTERNAL LINKS
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