| Receptor Tyrosine Kinase |
Article Index for Receptor |
Information AboutReceptor Tyrosine Kinase |
| CATEGORIES ABOUT RECEPTOR TYROSINE KINASE | |
| tyrosine kinase receptors | |
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Receptor tyrosine kinases have been shown to be not only key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of Cancer .1 RECEPTOR TYROSINE KINASE CLASSES Approximately 20 different RTK classes have been identified. www.genome.ad.jp {Link without Title} Retrieved on 2007-04-05 #RTK class I ( EGF Receptor Family ) #RTK class II ( Insulin Receptor family) #RTK class III ( PDGF Receptor family) #RTK class IV ( FGF Receptor family) #RTK class V ( VEGF Receptor family) #RTK class VI ( HGF Receptor family) #RTK class VII ( TRK receptor family) #RTK class VIII ( EPH Receptor family) #RTK class IX ( AXL receptor family) #RTK class X ( LTK receptor family) #RTK class XI ( family) #RTK class XII ( ROR receptor family) #RTK class XIII ( DDR receptor family) #RTK class XIV ( RET Receptor family) #RTK class XV ( KLG receptor family) #RTK class XVI ( RYK Receptor family) #RTK class XVII ( MuSK Receptor family) STRUCTURE Most RTKs are single subunit receptors but some e.g. the Insulin Receptor exist as Multimeric Complexes . Each Monomer has a single Transmembrane spanning Domain composed of 25-38 Amino Acid s, an Extracellular N-terminal region and an Intracellular C-terminal region. The extracellular N-terminal region is composed of a very large Protein Domain which binds to extracellular Ligands e.g. a particular Growth Factor or Hormone . The intracellular C-terminal region comprises domains responsible for the Kinase activity of these receptors. KINASE ACTIVITY In Biochemistry , a ''kinase'' is a type of Enzyme that transfers Phosphate groups (see below) from High-energy donor molecules, such as ATP (see below) to specific target molecules ( Substrate s); the process is termed '' Phosphorylation ''. The opposite and an enzyme that removes phosphate groups from targets is known as a Phosphatase . Kinase enzymes that specifically phosphorylate tyrosine amino acids are termed Tyrosine Kinases |
Image:ATP Chemical Structurepng<center>'''
| "http://wwwinformationdelightinfo/information/entry/Adenosine_triphosphate" class="copylinks">ATP '''</center> |
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| "http://wwwinformationdelightinfo/information/entry/Tyrosine" class="copylinks">Tyrosine '''</center> |
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