- Raster Transfer Language , the Hewlett-Packard's Raster Transfer Language.
- Reggaeton Latino , a type of Latin music partly influenced by Reggae .
- Recombinant T Cell Receptor Ligand , a new class of small soluble polypeptide useful in detecting and regulating T cells.
- Register Transfer Level , a design/description of digital integrated circuits in electronic design automation
- Register Transfer Language , In programming language compilers, an intermediate representation used in the GNU Compiler Collection
- Run-time Library , in software engineering
- A real-time language written by J.G.P. Barnes of ICI in 1971
- A small real-time language based on ALGOL 68 , with separate compilation designed by J.G.P. Barnes of ICI in 1972 as a successor to '''RTL/1'''
- ''Right-to-left writing'', as applied in Arabic and Hebrew. See Bi-directional Text and Writing System#Directionality .
- Republic Of Timor-Leste
- Resistor-transistor Logic , an obsolete circuit design for computer logic gates
- The RTL Group , a major media company, and many of their stations:
- --- RTL Television , one of the main German TV stations
- --- RTL II , also a German TV station
- --- Super RTL , another German TV station
- --- RTL 4 Dutch TV station of the RTL Group
- --- RTL 5 Dutch TV station of the RTL Group
- --- RTL 7 Dutch TV station of the RTL Group
- --- RTL 8 Dutch TV station of the RTL Group
- --- RTL 9 a French language TV station of the RTL Group
- --- '' RTL Télé Lëtzebuerg '' (in Luxembourgish) or ''Radio Télé Luxemburg'' (in German), the main brand of the RTL Group
- --- RTL Klub , Hungarian TV station of the RTL Group
- --- RTL Televizija , the Croatian Language TV station of the RTL Group
- --- RTL (French Radio) , a French radio station
- --- RTL-TVI and Club RTL , French-language TV channels from Belgium
- RTL 102.5 (Italian radio) (Not owned by RTL Group )
- Regent Three (Leyland) , A bus operated by London Transport in the 1950s
- Realtek Semiconductor Corp., a Taiwanese company
- Réseau De Transport De Longueuil , a public transit carrier in the city of Longueuil, Quebec, Canada
- Ride The Lightning , the second studio album released by the thrash metal band, Metallica
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