- Remote Procedure Call , a protocol that allows a computer program running on one host to cause code to be executed on another host
- Revolutionary Policy Committee , a faction within the Independent Labour Party, a United Kingdom political party during the 1930s
- Rail Passengers Council , a network established by the Parliament of the United Kingdom to protect and promote the interests of rail passengers throughout Great Britain
- Royal Parks Constabulary , a police force that was responsible for the eight Royal Parks of London and a number of other locations in London, England
- ''Rules of Professional Conduct'', relating to U.S. lawyers' ethical rules, see American Bar Association Model Rules Of Professional Conduct
- ''Regional playback control'', a form of regional lockout implemented on DVDs, see DVD Region Code
- ''République Populaire de Chine'', the French name for the People's Republic Of China
- ''Rocket Pod Container'', the interchangeable containers used to transport and launch missiles for use with the M270 Multiple Launch Rocket System
- ''Resistive plate chamber'', a simple type of Particle Detector used in experimental particle physics
- ''Role-playing Council'', an elected party of players of the Legend Of The Jedi Multi-user Dungeon working to enforce the set of rules established to preserve the game as a place where a multitude of people can find enjoyment
- ''Rosetta Plasma Consortium'', a consortium of five sensors {Link without Title} on board of the Rosetta Space Probe that was launched in 2004 intended to study the comet 67P/Churyumov-Gerasimenko
- ''Republican Policy Committee'' in the U.S. Senate {Link without Title}
- Rich Photorealistic Content
- Radiological Physics Center , The Radiological Physics Center (RPC) is a non-profit organization funded by NCI with the purpose of promoting excellence in the quality of radiation therapy clinical trials.
- Recurrent Pyogenic Cholangitis , a medical condition especially common in Asians.
- ''Readers Per Copy'', the number of people who read a single copy of a Magazine . This is a useful distinction in examining magazines' Demographic trends.
- Research Policy Council, the executive management team for the Congressional Research Service , a division of the Library Of Congress .
- Root Path Costs, is a field within the BPDU of the spanning tree protocol
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