(also known as '''Parkinson's syndrome''', '''atypical Parkinson's''', or '''secondary Parkinson's''') is a neurological
Syndrome characterized by
Tremor ,
Hypokinesia ,
Rigidity , and
Postural Instability .
1 The underlying causes of parkinsonism are numerous, and diagnosis can be complex.
2 While the
Neurodegenerative condition
Parkinson's Disease (PD) is the most common cause of parkinsonism, a wide-range of other
Etiologies can lead to a similar set of symptoms, including some
Toxins , a few
Metabolic Disease s, and a handful of non-PD neurological conditions.
3
If PD has been excluded, the
Differential Diagnosis or list of potential causes for this syndrome includes:
- AIDS can sometimes lead to the symptoms of Parkinson's disease, due to commonly causing dopaminergic dysfunction.4
- Corticobasal Degeneration
- Creutzfeldt-Jakob Disease 5
- Diffuse Lewy Body Disease
- Drug-induced parkinsonism (due to drugs such as Antipsychotics , Metoclopramide , MPTP 6)
- Encephalitis Lethargica
- Multiple System Atrophy 7
- Pantothenate Kinase-associated Neurodegeneration (Hallervorden-Spatz syndrome)8
- Progressive Supranuclear Palsy
- Toxicity due to substances such as Carbon Monoxide ,9 Carbon Disulfide , Manganese , Paraquat ,10 Hexane , Rotenone , and Toluene .
- Vascular Parkinsonism11
- Wilson's Disease is a genetic disorder in which there is an abnormal accumulation of copper. The excess copper can lead to the formation of a copper-dopamine complex, which leads to the oxidation of dopamine to aminochrome.12
- Paraneoplastic Syndrome (PNS). A neurological disease related to incipient cancer which manifests itself with neurological symptoms similar to actual neurological diseases or disorders.
