- Microsoft Points , the currency used on the Xbox Live and Zune marketplaces
- Managing Successful Programmes , the OGC approach to Programme Management
- Microsoft Student Partners , an organization of University students interested in careers in technology who are willing to help others learn about Microsoft technology
- Microsoft Project , project management software program developed and sold by Microsoft
- Microsoft Installer Patch Files , files that are downoladed from updating applications installed with Microsoft Installer and have the .msp file extension
- Member Of The Scottish Parliament , title given to any one of the 129 individuals elected to serve in the Scottish Parliament
- Minneapolis-St. Paul , the twin cities of Minneapolis and St. Paul and the surrounding area is the most highly populated area in Minnesota, USA
- --- Minneapolis-Saint Paul International Airport , IATA airport code
- --- Midway (Amtrak Station) , in St. Paul, Minnesota, United States
- MSP (file Format) , a pre-bmp picture format readable in the oldest versions of Microsoft Paint
- Movement Of Society For Peace , an Algerian political party
- '' Merozoite Surface Protein '', in malaria study
- Malabar Special Police , a paramilitary unit of the State Police of Kerala, India; equivalent to a SWAT team in the United States
- Michigan State Police , state police agency for the State of Michigan, USA
- Maryland State Police , official state police force of the State of Maryland, USA
- Massachusetts State Police , an agency of the Commonwealth of Massachusetts' Executive Office of Public Safety responsible for criminal law enforcement and traffic vehicle regulation
- Max/MSP , max signal processing
- Manic Street Preachers , a Welsh rock band
- Managed Service Provider , a business model for providing IT Service
- Medical Services Plan , government-administered single-payer health insurance scheme in the Canadian province of British Columbia
- Major Sperm Protein , the most abundant protein in nematode sperm
- Matchstick Productions , an extreme sport video production company sepcializing in skiing
- Member Service Provider , establishes merchant accounts
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