- James Hamilton, 1st Duke Of Hamilton (1606–1649), heir to the throne of Scotland
- James Hamilton, 4th Duke Of Hamilton ( 1658 – 1712 ), Scottish nobleman
- James Hamilton, 5th Duke Of Hamilton ( 1703 – 1743 ), Scottish nobleman
- James Hamilton, 6th Duke Of Hamilton ( 1724 – 1758 ), Scottish nobleman
- James Hamilton, 7th Duke Of Hamilton ( 1755 – 1769 , Scottish nobleman
- James Hamilton, 1st Duke Of Abercorn (1811–1885), twice served as Lord Lieutenant of Ireland
- James Hamilton, 2nd Duke Of Abercorn (1838–1913), British nobleman and diplomat
- James Hamilton, 3rd Duke Of Abercorn (1869–1953), the first Governor of Northern Ireland
- James Hamilton, 4th Duke Of Abercorn (1904–1979), Northern Irish senator
- James Hamilton, 5th Duke Of Abercorn (b. 1934), Northern Irish politician
- James Hamilton, 1st Earl Of Arran (c. 1475–1529), Scottish nobleman
- James Hamilton, 2nd Earl Of Arran (c. 1516–1575), Scottish nobleman
- James Hamilton, 3rd Earl Of Arran (c. 1537–1609), Scottish nobleman
- James Hamilton, 1st Earl Of Abercorn (c. 1575–1618), Sheriff of Linlithgow
- James Hamilton, 2nd Earl Of Abercorn (c. 1604 – c. 1670), Scottish nobleman
- James Hamilton, 6th Earl Of Abercorn (c. 1661–1734), Scottish and Irish nobleman
- James Hamilton, 7th Earl Of Abercorn (1686–1774), Scottish nobleman and amateur scientist
- James Hamilton, 8th Earl Of Abercorn (1712–1789), Scottish and Irish nobleman
- James Hamilton, 1st Lord Hamilton (d. 1479), Scottish nobleman
- James Hamilton Of Finnart (d. 1540), military engineer, illegitimate son of the 1st earl and guardian to the 2nd
- James Hamilton, 3rd Baron Hamilton Of Strabane (1633–1655), Irish nobleman
- James Hamilton, Viscount Hamilton (1786–1814), British politician
- James Douglas-Hamilton, Baron Selkirk Of Douglas (b. 1942), member of the Scottish Parliament
- James Hamilton (colonel) (c. 1620-1673), a favorite of Charles II
- James Hamilton (bishop) (1610–1674), bishop of Galloway
- James Hamilton (Pennsylvania) (c. 1710–1783), son of Andrew Hamilton, mayor of Philadelphia and lieutenant-governor of Pennsylvania
- James Inglis Hamilton (d. 1803), Major General in the British Army
- James Inglis (Anderson) Hamilton (1777–1815), British army colonial
- James Hamilton, Jr. (1786–1857), Governor and Representative for South Carolina
- James Stevenson-Hamilton (1867–1957), founder of the Kruger National Park, South Africa
- Neil Hamilton (actor) , (1899-1984) American actor
- James Hamilton (Scottish Politician) (1918–2005), Scottish politician
- Jim Hamilton , Scottish footballer
- James Hamilton (jurist) (fl. 2000s), Irish
- Jim Hamilton (footballer) , Scottish rugby union footballer
- Jamie Hamilton , a half-American half-Scottish book publisher and champion oarsman who was born ''James Hamilton''
- James A. Hamilton , father of Alexander Hamilton , fourth son of Mr. Alexander Hamilton of Grange, Ayrshire
|
