- A.J. Jacobs
- Bert Jacobs
- Brandon Jacobs , American Football player
- Charles Fenno Jacobs
- Christian Jacobs , lead singer of The Aquabats and co-creator of '' Yo Gabba Gabba! ''
- Christian Friedrich Wilhelm Jacobs (1764–1847)
- Edgar Pierre Jacobs
- George Jacobs , inventor
- Glen Jacobs
- Harriet Ann Jacobs
- Helen Hull Jacobs
- Hirsch Jacobs
- Jack H. Jacobs , Medal of Honor recipient.
- Jane Jacobs , Canadian urbanist (born 1916)
- Jon Jacobs , freelance writer and BDSM activist
- Joseph Jacobs
- Lawrence Jacobs
- Melville Jacobs
- Nancy Jacobs , American politician
- Paul Jacobs (pianist) , U.S. pianist
- R.P.J. Jacobs Guidisme Et Scoutisme En Belgique member of the World Scout Committee of the World Organization Of The Scout Movement from 1929 until 1931
- Steve Jacobs , an Australian actor
- Steven Jacobs , another Australian actor and presenter
- Steve Jacobs (meteorologist) , a meteorologist for CFTO ( CTV , prior to 1997 also at Baton )
- Thornwell Jacobs
- W. W. Jacobs
- Jacob Johnson (father Of Andrew Johnson) , the father of the seventeenth President of the United States
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