- William Irvine (Scotland) (c. 1298–?), Clerk of the Roles for Scotland
- William Irvine (physician) (1741-1804), Revolutionary soldier, U.S. Congressman from Pennsylvania
- William Irvine (lawyer) (1820-1882), Civil War soldier, U.S. Congressman from New York
- Acheson Irvine (1837–1916), Commissioner of the Royal Canadian Mounted Police
- Andrew Irvine (mountaineer) (1902–1924), British mountaineer who died attempting to climb Everest
- William Irvine (Australian Politician) (1858–1943), Australian politician and judge
- William Irvine (Scottish Evangelist) (1863-1947), Scottish Presbyterian evangelist
- James Irvine (chemist) (1877-1952), chemist and vice-chancellor of the University of St Andrews
- Olive Lillian Irvine (1895–1969), Canadian teacher and politician
- Derry Irvine, Baron Irvine Of Lairg (born 1940), British lawyer and Lord Chancellor
- Andy Irvine (musician) (born 1942), Irish folk musician
- Andy Irvine (rugby Player) (born 1951), Scottish rugby player
- Eddie Irvine (born 1965), Northern Irish racing driver
- Brian Irvine (born 1965), Northern Irish composer
- James Irvine (educator) , second president of Ohio University
- James Irvine (landowner) , co-founder of the Irvine Ranch
- James Irvine, Jr. , son of James Irvine, founder of the Irvine Company
- John Irvine (journalist) , Northern Irish journalist
- Ian Irvine (born 1950), Australian fantasy/eco-thriller author and marine scientist.
- Irvine Kinneas , playable character in the video game ''Final Fantasy VIII''
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- Irvine, Alberta , Canada
- Irvine, Ayrshire , Scotland
- Irvine, California , USA
- --- The University Of California, Irvine , a public research university
- --- The Irvine Company , owner of a ranch comprising nearly a third of Orange County, California
- Irvine, Kentucky , USA
- Irvine Valley , Ayrshire, Scotland
- River Irvine , a river in Scotland
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