- Formally, can refer to '' International Sign Language '', aka Gestuno, or to '' Indian Sign Language ''
- Informally, can refer to Irish Sign Language
- More formally, is the SIL Code for Israeli Sign Language
- A Trotskyist group in Germany, International Socialist Left (internationale sozialistische linke, isl)
- is the NATO Country Code for Iceland
- In mathematics, can stand for In The Sense Of Lyapunov
- In reference to a Storage Area Network , and switched networks stands for Inter Switch Link
- Cisco Inter-Switch Link , a proprietary Cisco protocol
- Ice Hockey Superleague , British based league (1996–2003)
- Illinois Security Lab
- Intercon Security , a security firm
- International Synergies Limited , a UK company
- International School Of Luxembourg
- Island Line
- Institute Of Sigma Learning
- IBM India Software Lab IBM ISL
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