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Heterocyclic compounds are organic Compounds that contain a ring structure containing atoms in addition to Carbon , such as Sulfur , Oxygen or Nitrogen , as part of the ring. They may be either Simple Aromatic Ring s or non-aromatic rings. Some examples are Pyridine (C5H5N), Pyrimidine (C4H4N2) and Dioxane (C4H8O2). Note that compounds such as '' Cyclopropane '', an anaesthetic with explosive properties, and '' Cyclohexane '', a solvent, are not heterocyclic, they are merely Cycloalkanes . The suffix '-cyclic' implies a ring structure, while 'hetero' refers to an atom other than carbon, as above. Many heterocyclic compounds, including some Amines , are Carcinogenic . Heterocyclic chemistry is the chemistry branch dealing exclusively with synthesis, properties and applications of heterocycles especially vital to Drug design. 3-MEMBERED RINGS Heterocycles with three atoms in the ring are more reactive because of Ring Strain . Those containing one heteroatom are generally stable. Those with two heteroatoms are more likely to occur as reactive intermediates. Common 3-membered heterocycles are: 4-MEMBERED RINGS 5-MEMBERED RINGS With heterocycles containing five atoms, the Unsaturated Compounds are frequently more stable because of Aromaticity . With two heteroatoms:
6-MEMBERED RINGS With two heteroatoms:
HETEROCYCLIC AMINES AND CANCER Some heterocyclic amines (HCAs) found in cooked meat are known Carcinogen s. Research has shown that cooking certain meats at high temperatures creates chemicals that are not present in uncooked meats. For example, heterocyclic amines are the carcinogenic chemicals formed from the cooking of muscle meats such as Beef , Pork , Fowl , and Fish . HCAs form when Amino Acids and Creatine (a chemical found in muscles) react at high cooking temperatures. Researchers have identified 17 different HCAs resulting from the cooking of muscle meats that may pose human cancer risk.1 NCI's Division of Cancer Epidemiology and Genetics found a link between individuals with Stomach Cancer and the consumption of cooked meat, and other studies for Colorectal , Pancreatic , and Breast Cancer is associated with high intakes of well-done, fried, or Barbecue d meats. Other sources of Protein ( Milk , Eggs , Tofu , and organ meats such as Liver ) have very little or no HCA content naturally or when cooked. REFERENCES EXTERNAL LINKS
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