- Computer-aided Diagnosis (medical), an inter-discipline combining computer science and radiography to support the diagnostic process
- Computer Assisted Detection (medical)
- Computer-aided Design , a wide range of computer-based tools that assist engineers, architects and other design professionals
- Cadoxton Railway Station , serving the village of Cadoxton near Barry, Vale of Glamorgan
- Canadian Dollar , the currency of Canada
- Capital Adequacy Directive , a European directive that aims to establish uniform capital requirements for both banking firms and non-bank securities firms
- Children Of The Anachronistic Dynasty , an industrial and alternative rock band that formed in the 1980s
- Cold Air Damming , a meteorological phenomenon that involves a high pressure system
- Computer-assisted Dispatch , a method of dispatching taxicabs, couriers, field service technicians, or emergency services
- Coronary Artery Disease , AKA coronary heart disease
- '' Ctrl+Alt+Del '', a gaming-related webcomic and animated series
- Cylindrical Algebraic Decomposition
- Current Account Deficit , in the balance of payments
- Wexford County Airport , IATA airport code: CAD, in Cadillac, Michigan, United States
- Cad (character) , a man who seduces a young woman and impregnates her before leaving, often to her social or financial ruin
- Cash Against Documents payment terms and conditions that appoint your bank as consignee for the shipment and as paying agent
- Cadiz Railroad , AAR reporting marks "CAD"
- Confined Aquatic Disposal
- Crank Angle Degree (automotive)
- Conneaut Audio Devices (microphones)
- Card Acceptance Device
- Caspase-activated DNAase
- Central Ammunition Depot . A United Kingdom term; many CADs have been downgraded to Base Ammunition Depots (BADs)
- Civil Aviation Department , a department in the Hong Kong Government
- Caddy , the person who carries a golfer's bag
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