| C3 (complement) |
Article Index for C3 |
Information AboutC3 (complement) |
In immunology, soluble C3-convertase , also known as iC3Bb, catalyzes the Proteolytic cleavage of C3 into C3a and C3b as part of the Alternative Complement System . C3A C3a plays an important role in Chemotaxis , though not as important a role as C5a . It is also an Anaphylatoxin . C3B C3b may bind to Microbial cell surfaces within an organism's body. This can lead to the production of surface-bound C3 convertase and thus more C3b components. Also known as C3bBb, this convertase is similar to soluble C3-convertase except that it is membrane bound. Alternatively, bound C3b may aid in Opsonization of the microbe by Macrophages . Complement Receptor 1 or CR1 on macrophages allows the engaging of C3b covered microbes. C3b is cleaved into C3c and C3d. SEE ALSO REFERENCES EXTERNAL LINKS
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