- Eight-ball , a pocket billiards (pool) game
- The as used in pool
- 8-Ball , a character in the ''Grand Theft Auto III'' video game
- Don "8-Ball" Harris , a professional wrestler
- Magic 8-Ball , a toy that resembles the pool ball and purports to tell fortunes
- Eightball Gun , a fictional weapon featured in the ''Unreal'' computer game series
- Slang for one-eighth ounce (3.5g) of a Psychoactive Drug (especially cocaine, heroin, or crystal methamphetamine)
- A nickname for the Olde English 800 brand of malt liquor
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