Year (''' MDCCCXXI ''') was a Common Year Starting On Monday (link will display the full calendar) of the Gregorian Calendar (or a Common Year Starting On Saturday of the 12-day slower Julian Calendar ).
- January 8
- --- James Longstreet , American Confederate general (d. 1904 )
- --- W.H.L. Wallace , American Civil War general (d. 1862 )
- February 3 - Elizabeth Blackwell , first American female physician (d. 1910 )
- February 11
- --- Hermann Allmers , writer (d. 1902 )
- --- Auguste Edouard Mariette , French Egyptologist (d. 1881 )
- February 17 - Lola Montez , Irish Spanish dancer and royal mistress (d. 1861 )
- February 19 - August Schleicher , German linguist (d. 1868 )
- March 1 - Joseph Hubert Reinkens , German Old Catholic bishop (d. 1896 )
- March 15 - William Milligan , Scottish theologian (d. 1892 )
- April 3 - Fr. Thomas Pelham Dale English mystic (d. 1892 )
- April 9 - Charles-Pierre Baudelaire , French poet and writer (d. 1867 )
- May 8 - William Henry Vanderbilt , American entrepreneur (d. 1885 )
- May 16 - Pafnuty Chebyshev , Russian mathematician (d. 1894 )
- May 17 - Sebastian Kneipp , German naturopath (d. 1897 )
- July 1 - Anatole Jean-Baptiste Antoine De Barthélemy , French archaeologist (d. 1904 )
- July 18 - Pauline Garcia-Viardot , French mezzo-soprano and composer (d. 1910 )
- August 10 - Jay Cooke , American financier (d. 1905 )
- September 28 - Jonathan Clarkson Gibbs African-American minister and politician (d. 1874 )
- October 13 - Rudolf Virchow , German physician, pathologist, biologist, and politician (d. 1902 )
- November 11 - Fyodor Dostoevsky , Russian writer (d. 1881 )
- November 30 - Frederick Temple , Archbishop Of Canterbury (d. 1902 )
- December 12 - Gustave Flaubert , French writer (d. 1880 )
- December 25 - Clara Barton , First president of American Red Cross (d. 1912 )
- Sir John Joseph Caldwell Abbott , Canadian politician (d. 1893 )
: ''See also .''
: ''See also .''
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