Year (''' MDCXXI ''') was a Common Year Starting On Friday (link will display the full calendar) of the Gregorian Calendar (or a Common Year Starting On Monday of the 10-day slower Julian Calendar ).
- January 27 - Thomas Willis , English physician who made important contributions to anatomy, particularly of the brain and nervous system (d. 1675 )
- February 2 - Johannes Schefferus , Alsatian-born humanist (d. 1679 )
- February 21 - Rebecca Nurse , accused witch (d. 1692 )
- March 31 - Andrew Marvell , English poet (d. 1678 )
- April 1 - Guru Teg Bahadur , 9th Sikh Guru (d. 1675 )
- April 25 - Roger Boyle, 1st Earl Of Orrery , British soldier, statesman, and dramatist (d. 1679 )
- July 6 - Jean De La Fontaine , French writer (d. 1695 )
- July 22 - Anthony Ashley-Cooper, 1st Earl Of Shaftesbury , British politician (d. 1683 )
- August 19 - Gerbrand Van Den Eeckhout , Dutch painter (d. 1674 )
- September 8 - Louis II De Bourbon, Prince De Condé , French general (d. 1686 )
- December 23 - Edmund Berry Godfrey , English magistrate (d. 1678 )
- December 23 - Heneage Finch, 1st Earl Of Nottingham , Lord Chancellor Of England (d. 1682 )
: ''See also .''
- January 28 - Pope Paul V (b. 1550 )
- February 15 - Michael Praetorius , German composer (born 1571 )
- February 28 - Cosimo II De' Medici, Grand Duke Of Tuscany (b. 1590 )
- March 31 - King Philip III Of Castile (Philip II of Portugal ) (b. 1578 )
- April 1 - Cristofano Allori , Italian painter (b. 1577 )
- April 15 - John Carver , first governor of Plymouth Colony
- May 15 - Hendrick De Keyser , Dutch architect and sculptor (b. 1565 )
- June 8 - Anne De Xainctonge , French saint (b. 1567 )
- June 21 - Kryštof Harant Z Polžic A Bezdružic , Bohemian composer, soldier, and author (executed) (b. 1564 )
- July 2 - Thomas Harriot , English astronomer and mathematician (born c 1560 )
- July 10 - Karel Bonaventura Buquoy , French soldier (b. 1571 )
- July 13 - Archduke Albert Of Austria , Governor of the Low Countries (b. 1559 )
- August 3 - Guillaume Du Vair , French writer (b. 1556 )
- August 15 - John Barclay , Scottish writer (b. 1582 )
- September 17 - Robert Bellarmine , Italian saint (b. 1542 )
- September 24 - Jan Karol Chodkiewicz , Polish military commander (b. 1560 )
- September 25 - Mary Sidney , English writer, patroness and translator (b. 1561 )
- October 8 - Antoine De Montchrestien , French dramatist and economist (born c 1575 )
- October 16 - Jan Pieterszoon Sweelinck , Dutch commposer (b. 1562 )
- November 26 - Ralph Agas , English surveyor (born c 1540 )
- December 13 - Katarina Stenbock , queen of Gustav I Of Sweden (b. 1535 )
- December 15 - Charles De Luynes , Constable of France (b. 1578 )
- ''date unknown'' - Dirk Hartog , Dutch explorer (b. 1580 )
: ''See also .''
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