: Cortés .]]
Year ( MDXIX ) was a Common Year Starting On Saturday (link will display the full calendar) of the Julian Calendar .
: Magellan begins voyage.]]
: Aztec s at Tenochtitlán .]]
- February 5 - René Of Châlon , Prince of the House of Orange (d. 1544 )
- February 15 - Pedro Menéndez De Avilés , first Spanish Governor of Florida (d. 1574 )
- February 16 - Gaspard De Coligny , French Huguenot leader (died 1572 )
- February 17 - Francis, Duke Of Guise , French soldier and politician (d. 1563 )
- March 31 - King Henry II Of France (died 1559 )
- April 13 - Catherine De' Medici , queen of Henry II Of France (died 1589 )
- May 27 - Girolamo Mei , Italian humanist historian (died 1594 )
- June 6 - Andrea Cesalpino , Italian philosopher, physician, and botanist (died 1603 )
- June 12 - Cosimo I De' Medici, Grand Duke Of Tuscany (died 1574 )
- June 24 - Theodore Beza , French theologian (died 1605 )
- July 22 - Pope Innocent IX (died 1591 )
- ''date unknown''
- --- Thoinot Arbeau , French priest and author (died 1596 )
- --- Johannes Goropius Becanus , Dutch physician, linguist, and humanist (d. 1572 )
- --- Nicholas Grimald , English poet (died 1562 )
- --- Ikeda Nagamasa , Japanese military commander (died 1563 )
- --- Edwin Sandys , English prelate (died 1588 )
- --- Imagawa Yoshimoto , Japanese warlord
- --- Stanisław Zamoyski , Polish nobleman (died 1572 )
- ''probable''
- --- Thomas Gresham , English merchant and financier (died 1579 )
- January 12 - Maximilian I, Holy Roman Emperor (born 1459 )
- January 21 - Vasco Núñez De Balboa , Spanish explorer (born 1475 )
- March 29 - Francesco II Gonzaga, Marquess Of Mantua (born 1466 )
- May 2 - Leonardo Da Vinci , Italian inventor and painter (born 1452 )
- May 4 - Lorenzo II De' Medici , Duke of Urbino (b. 1492 )
- June 24 - Lucrezia Borgia , Duchess of Ferrara (born 1480 )
- August 11 - Johann Tetzel , German opponent of the Reformation (born 1465 )
- August 23 - Philibert Berthelier , Swiss patriot (born c 1465 )
- September 10 - John Colet , English churchman and educator (born 1467 )
- ''date unknown''
- --- William Grocyn , English scholar (born 1446 )
- --- Cho Kwangjo , Korean scholar(born 1482 )
- --- Ambrosius Holbein , German painter (born 1494 )
- --- Alonso Álvarez De Pineda , Spanish explorer and cartographer (born 1494 )
: ''See also .''
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