may mean:
;In Canada
;United Kingdom
- Upton, Berkshire
- Upton, Buckinghamshire
- Upton, Cambridgeshire
- Upton, Cheshire
- Upton, Cornwall
- Upton, Cumbria
- Upton, Devon
- Upton, Dorset
- Upton, Hampshire
- Upton, Leicestershire
- Upton, Lincolnshire
- Upton, London
- Upton, Merseyside
- Upton, Norfolk
- Upton, Northamptonshire
- Upton, Nottinghamshire
- Upton, Oxfordshire
- Upton, Pembrokeshire
- Upton, Slough
- Upton, Somerset
- Upton, Warwickshire
- Upton, West Yorkshire
- Upton, Wiltshire
- Upton, Wirral
Also:
- Upton Cum Chalvey , Slough
- Upton-upon-Severn , Worcestershire
- Upton Cheyney , South Gloucestershire
- Hawkesbury Upton , South Gloucestershire
- Upton Fen , Norfolk
- Upton House , Warwickshire
- Upton Magna , Shropshire
- Upton Park , Newham, London
- Upton Scudamore , Wiltshire
;United States of America
- B.J. Upton , (b 1984), American baseball player
- Charles W. Upton , economist
- Clive Upton , consultant, Oxford Dictionary
- Emory Upton , (1839-1881), US army general
- Fred Upton , (b 1953), American politician
- Graham Upton , Vice-Chancellor, Oxford Brookes University
- James Upton , (1888-1949) British soldier awarded the Victoria Cross
- Lawrence Upton , (b 1949), poet and artist
- Mary Upton , Irish politician
- Simon Upton , (b 1958), New Zealand politician
- Steve Upton , (b 1946), Wishbone Ash drummer
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