| Transforming Growth Factor |
Website Links For Growth |
Information AboutTransforming Growth Factor |
| CATEGORIES ABOUT TRANSFORMING GROWTH FACTOR | |
| growth factors | |
| signal transduction | |
|
TGFΑ TGFα is upregulated in some human Cancer s. It is produced in Macrophage s, Brain cells, and Keratinocyte s, and induces Epithelial development. It is closely related to EGF , and can also bind to the EGF Receptor with similar effects . TGFα stimulates neural cell Proliferation in the adult injured brain . TGFα was cited in the 2001 NIH Stem Cell report to the U.S. Congress as promising evidence for the ability of adult stem cells to restore function in neurodegenerative disorders. TGFΒ TGFβ exists in at least three known subtypes in humans, TGFβ1, TGFβ2, and TGFβ3. These are upregulated in some human cancers, and play crucial roles in Tissue Regeneration , Cell Differentiation , and Embryonic Development . TGFβ1 frequently exerts a growth inhibitory role on epithelial cells, becoming expressed at high levels late in regenerative processes as cell division comes to an end. The TGFβ Superfamily includes other homologous Ligands including Activin and Bone Morphogenetic Proteins . THE TGF RECEPTOR TGFβ receptors are single pass Serine/threonine Kinase Receptor s. They exist in several different Isoform s that can be Homo - or Heterodimeric . The number of characterized ligands in the TGFβ superfamily far exceeds the number of known receptors, suggesting the promiscuity that exists between the Ligand and receptor interactions. TGF can be found in many different Tissue types, including brain, Heart , Kidney , Liver and Testes . Over- Expression of TGF can induce Renal Fibrosis , causing Kidney Disease , as well as Diabetes , and ultimately End-stage Renal Disease (ESRD). Recent developments have found that, using certain types of protein Antagonist s against TGFβ receptors, can halt and in some cases reverse the effects of renal fibrosis. REFERENCES |
|
|