Thyrotropin-releasing Hormone

Thyrotropin-releasing hormone ('''TRH'''), also called '''thyrotropin-releasing factor''' ('''TRF'''), is a Tripeptide Hormone that stimulates the release of Thyroid-stimulating Hormone and Prolactin by the Anterior Pituitary . TRH is produced by the Hypothalamus and travels across the Median Eminence to the pituitary via the Hypophyseal Portal System .

In addition to the brain, TRH can also be detected in other areas of the body including the Gastrointestinal System and Pancreatic Islets . Medical preparations of TRH are used in diagnostic tests of Thyroid disorders and in Acromegaly .

The sequence of TRH was first determined and the hormone synthesized by Roger Guillemin and Andrew V. Schally in 1969 . Its molecular weight is 359.5 Da and its structure is:

(pyro)Glu-His-Pro-NH₂

REFERENCES

Boler J, Enzmann F, Folkers K, Bowers CY, Schally AV. ''The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide.'' Biochem Biophys Res Commun 1969;37:705-10. PMID 4982117.

Burgus R, Dunn TF, Desiderio D, Guillemin R. ''Molecular structure of the hypothalamic hypophysiotropic TRF factor of ovine origin: mass spectrometry demonstration of the PCA-His-Pro-NH2 sequence.'' Comptes Rendus hebdomadaires des Séances de l’Académie des Sciences 1969;269:1870–1873.

EXTERNAL LINK

	CATEGORIES ABOUT THYROTROPIN-RELEASING HORMONE

	hormones of the hypothalamus

	hpt axis

	peptide hormones

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