| Substance P |
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Information AboutSubstance P |
| CATEGORIES ABOUT SUBSTANCE P | |
| neuropeptides | |
| substance p | |
| neurotransmitters | |
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Substance P is an 11- substance P has been associated in the regulation of Mood Disorders , Anxiety , Stress , Reinforcement , Neurogenesis , Neurotoxicity , Nausea / Emesis and Pain . It also has effects as a potent vasodilator. This is caused by the release of nitric oxide from the endothelium. Its release can cause Hypotension . The Endogenous Receptor for Substance P is Neurokinin 1 receptor (NK1-receptor, NK1R). It belongs to the Tachykinin receptor sub-family of GPCR s. Substance P antagonist (SPA) Aprepitant is available in the market in the treatment of Chemotherapy -induced nausea / emesis. Substance P is involved in the transmission of Pain impulses from peripheral receptors to the Central Nervous System . It has been theorised that it plays a part in Fibromyalgia . Capsaicin has been shown to reduce the levels of Substance P probably by reducing the number of C-fibre nerves or causing these nerves to be more tolerant. Naked Mole Rat s lack Substance P and do not feel pain when painful stimuli are administered. EXTERNAL LINKS
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