| Osteoblast |
Articles about Osteoblast |
Information AboutOsteoblast |
| CATEGORIES ABOUT OSTEOBLAST | |
| skeletal system | |
| connective tissue cells | |
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Osteoblasts arise when osteoprogenitor cells ( Mesenchymal Cell s), which are located near all bony surfaces and within the bone marrow, differentiate under the influence of Growth Factor s, such as fibroblast growth factor (FGF), Platelet-derived Growth Factor (PDGF), Transforming Growth Factor Beta (TGF-β) and other Bone Morphogenetic Protein s (BMPs). In addition to osteoid, osteoblasts also secrete Enzyme s that facilitate Mineral deposition within osteoid Matrices . They are also responsible for regulating the activity of Osteoclast s via soluble mediators. Osteoblasts that become trapped in the bone matrix become Osteocyte s. ACTIVATED OSTEOBLAST:The cytoplasm appear to be basophilic via normal H&E stain due to presence of large amount of RER A large Golgi apparatus is also present in the centre.The nucleus is spherical and large. |
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