| Monoamine Transporter |
Article Index for Monoamine |
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Information AboutMonoamine Transporter |
| CATEGORIES ABOUT MONOAMINE TRANSPORTER | |
| membrane biology | |
| neurotransmitter transporters | |
| integral membrane proteins | |
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There are several different Monoamine transporters.
DAT, NET and SERT are related to each other and they all consist of a structure of 12 Transmembrane Helices . DRUG ACTION Many drugs, such as Antidepressant s and Psychoactive s affect the monoamine transporters. Modern antidepressants typically work by enhancing serotonergic, noradrenergic or dopaminergic Neurotransmission by binding to the corresponding transporter, and thereby inhibiting neurotransmitter Reuptake and raising active levels in the Synapse . Examples include Fluoxetine , a Selective Serotonin Reuptake Inhibitor ; Reboxetine , a norepinephrine reuptake inhibitor and Bupropion , which inhibits both the norepinephrine and dopamine transporter. The Euphoric and Addictive properties of Amphetamine , Methamphetamine and Cocaine are thought to come from their potent DAT-blocking activity. SEE ALSO REFERENCES 1 |
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