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('''MVP''') is a
Heart Valve condition marked by the displacement of an abnormally thickened
Mitral Valve leaflet into the
Left Atrium during
Systole . In its nonclassic form, MVP carries a low risk of complications. In severe cases of classic MVP, complications include
Mitral Regurgitation ,
Infective Endocarditis , and — in rare circumstances —
Cardiac Arrest usually resulting in sudden
Death .
The
Mitral Valve , so named because of its resemblance to a
Bishop 's
Miter , is the
Heart Valve that prevents the backflow of
Blood from the left
Ventricle into the left
Atrium . It is composed of two leaflets (one anterior, one posterior) that close when the left ventricle contracts.
Each leaflet is composed of three layers of that thickens the spongiosa and separates
Collagen bundles in the fibrosa. This weakens the leaflets and adjacent tissue, resulting in increased leaflet area and elongation of the
Chordae Tendineae . Elongation of the chordae often causes rupture, and is commonly found in the chordae tendineae attached to the posterior leaflet. Advanced lesions — also commonly involving the posterior leaflet — lead to leaflet folding, inversion, and displacement toward the left atrium.
For many years, mitral valve prolapse was a poorly understood anomaly associated with a wide variety of both related and seemingly unrelated signs and symptoms, including late
Systolic Murmurs , inexplicable
Panic Attack s, and
Polythelia (extra
Nipple s). Recent studies suggest that these symptoms were incorrectly linked to MVP because the disorder was simply over-diagnosed at the time. Continuously-evolving criteria for diagnosis of MVP with
Echocardiography made proper diagnosis difficult, and hence many subjects without MVP were included in studies of the disorder and its prevalence. In fact, some modern studies report that as many as 55% of the population would be diagnosed with MVP if older, less reliable methods of MVP diagnosis — notably
M-mode Echocardiography — were used today. The term ''mitral valve prolapse'' was coined by Dr. Michael Criley in 1966 and gained acceptance over the other descriptor of "billowing" of the mitral valve (as described by Dr. Barlow).
In recent years, new criteria have been proposed as an objective measure for diagnosis of MVP using more reliable two- and three-dimensional echocardiography. The disorder has also been classified into a number of subtypes with respect to these criteria.
techniques which can pinpoint abnormal leaflet thickening and other related pathology.]]
Prolapsed mitral valves are classified into several subtypes, based on leaflet thickness, concavity, and type of connection to the mitral annulus. Subtypes can be described as classic, nonclassic, symmetric, asymmetric, flail, or non-flail.
Prolapse occurs when the mitral valve leaflets are displaced more than 2
Mm above the
Mitral Annulus high points. The condition can be further divided into classic and nonclassic subtypes based on the thickness of the mitral valve leaflets: up to 5 mm is considered nonclassic, while anything beyond 5 mm is considered classic MVP.
Classical prolapse may be subdivided into symmetric and asymmetric, referring to the point at which leaflet tips join the mitral annulus. In symmetric coaptation, leaflet tips meet at a common point on the annulus. Asymmetric coaptation is marked by one leaflet displaced toward the atrium with respect to the other. Patients with asymmetric prolapse are prone to severe deterioration of the mitral valve, with the possible rupture of the chordae tendineae and the development of a flail leaflet.
Asymmetric prolapse is further subdivided into flail and non-flail. Flail prolapse occurs when a leaflet tip turns outward, becoming concave toward the left atrium, causing the deterioration of the mitral valve. The severity of flail leaflet varies, ranging from tip eversion to chordal rupture. Dissociation of leaflet and chordae tendineae provides for unrestricted motion of the leaflet (hence "flail leaflet"). Thus patients with flail leaflets have a higher prevalence of
Mitral Regurgitation than those with the non-flail subtype.
Some patients with MVP experience
Heart Palpitation s,
Atrial Fibrillation , or
Syncope , though the prevalence of these symptoms does not differ significantly from the general population. Between 11 and 15 percent of patients experience moderate
Chest Pain and
Shortness Of Breath . These symptoms are most likely not caused directly by the prolapsing mitral valve, but rather by the mitral regurgitation that often results from prolapse.
For unknown reasons, MVP patients tend to have a low
Body Mass Index (BMI) and are typically leaner than individuals without MVP.
Upon
Auscultation of an individual with mitral valve prolapse, a mid-systolic click, followed by a late systolic
Murmur heard best at the apex is common.
Most cases of mitral valve prolapse are associated with mild
Mitral Regurgitation , where blood aberrantly flows from the left ventricle into the left atrium during
Systole . Approximately 7% of classic MVP patients experience severe regurgitation, often due to
Chordae Tendineae rupture.
Severe mitral valve prolapse is associated with
Arrhythmia s and
Atrial Fibrillation that may progress and lead to
Sudden Death . As there is no evidence that a prolapsed valve itself contributes to such arrythmias, these complications are more likely due to mitral regurgitation and
Congestive Heart Failure .
The major predictors of
Mortality are the severity of
Mitral Regurgitation and the
Ejection Fraction . Patients with moderate to severe mitral regurgitation have a relative risk for mortality that is three times that of the general population. Similarly, a left ventricular ejection fraction at or below 50% carries a relative risk of 3.8.
Echocardiography , a noninvasive method of visualizing the heart, is the most useful method of diagnosing a prolapsed mitral valve. Two- and three-dimensional echocardiography are particularly valuable as they allow visualization of the mitral leaflets relative to the mitral annulus. This allows measurement of the leaflet thickness and their displacement relative to the annulus. Thickening of the mitral leaflets above 2 mm indicates mitral valve prolapse.
Mitral valve prolapse can be treated with
Surgical Replacement of the mitral valve. This may be necessary in as many as 11% of patients with classic MVP, and is indicated for patients with an
Ejection Fraction below 60% and progressive left ventricular dysfunction.
People with mitral valve prolapse are at higher risk of
Infective Endocarditis (that is, bacterial infection of the heart tissue), as a result of surgical operations. Therefore they need preventive
Antibiotic Treatment , before any operation that involves massive bleeding. Minor skin wounds (and
Plastic Surgeries , etc), are not a problem, but dental operations such as
Pulpectomy ("
Root Canal ") are. Thus, as a risk lowering measure, people with Mitral valve prolapse should take extra care of their dental hygiene.
Figures vary widely, but most recent studies of mitral valve prolapse indicate a prevalence of 1.3% for classic and 1.1% for nonclassic MVP. MVP occurs less frequently in children, and does not vary significantly with sex. Though the reasons are not understood, patients with mitral valve prolapse tend to be leaner with a relatively low
Body Mass Index .
