runs between
U.S. Highway 65 at
Fair Grove and the
Arkansas state line, where it continues as
Arkansas State Highway 125 . It is a two-lane road its entire length. Near Chadwick, the highway enters the
Mark Twain National Forest and passes through this most of the way to Arkansas. It multiplexes with
Missouri State Highway 14 through most of Sparta. It also multiplexes with
U.S. Highway 160 for several miles at Rueter. After the road crosses into Arkansas, the highway crosses
Bull Shoals Lake via a free
Ferry .