| Malonic Acid |
Website Links For Acid |
Information AboutMalonic Acid |
| CATEGORIES ABOUT MALONIC ACID | |
| malonates | |
| dicarboxylic acids | |
|
Malonic acid (from Latin malum = apple) (1,3-propanedioic acid) is a Dicarboxylic Acid with structure C H 2( COOH )2. The Ion form of malonic acid, as well as its Ester s and Salt s, are known as '''malonates'''. For example, Diethyl Malonate is malonic acid's Ethyl Ester . BIOCHEMISTRY The Calcium salt of malonic acid occurs in high concentrations in Beetroot . Malonic acid inhibits Succinate Dehydrogenase in the Citric Acid Cycle . ORGANIC SYNTHESIS A classical preparation of malonic acid starts from Acetic Acid . This acid is chlorinated to chloroacetic acid. Sodium Carbonate generates the sodium Salt which is then reacted with Sodium Cyanide to the cyano acetic acid salt in a Nucleophilic Substitution . The Nitrile group can be Hydrolysed with Sodium Hydroxide to sodium malonate and acidification affords malonic acid. ORGANIC REACTIONS In a well known reaction malonic acid Condenses with Urea to Barbituric Acid . Malonic acid is frequently used as an Enolate in Knoevenagel Condensation s or condensed with Acetone to form Meldrum's Acid . EXTERNAL LINKS
REFERENCES |
|
|