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Lymphoma




Traditionally, Lymphoma is classified as Hodgkin's Lymphoma , discovered by Thomas Hodgkin in 1832 , and Non-Hodgkin's Lymphoma (all other types of lymphoma). Modern classifications of lymphoma are more sophisticated than this simple scheme.


CLASSIFICATION


WHO Classification


The WHO Classification is the latest classification of lymphoma, published by the World Health Organization in 2001. It was based upon the "Revised European-American Lymphoma classification" (REAL).

This classification attempts to classify lymphomas by cell type, i.e. the normal cell type that most closely resembles the tumour. They are classified in three large groups: the codes are provided where available)


Mature B Cell Neoplasms

  • ---Chronic lymphocytic leukemia/small lymphocytic lymphoma

  • ---B-cell prolymphocytic leukemia

  • ---Lymphoplasmacytic lymphoma/Waldenström macroglobulinemia

  • ---Splenic marginal zone lymphoma

  • ---Plasma cell neoplasms


  • --Plasma cell myeloma


  • --Plasmacytoma


  • --Monoclonal immunoglobulin deposition diseases


  • --Heavy chain diseases

  • ---Extranodal marginal zone B cell lymphoma (MALT lymphoma)

  • ---Nodal marginal zone B cell lymphoma

  • ---Follicular lymphoma

  • ---Mantle cell lymphoma

  • ---Diffuse large B cell lymphoma

  • ---Mediastinal (thymic) large B cell lymphoma

  • ---Intravascular large B cell lymphoma

  • ---Primary effusion lymphoma

  • ---Burkitt lymphoma/leukemia

  • ---lymphomatoid granulomatosis

  • Mature T cell and Natural Killer (NK) Cell Neoplasms

  • ---T cell prolymphocytic leukemia

  • ---T cell large granular lymphocytic leukemia

  • ---Aggressive NK cell leukemia

  • ---Adult T cell leukemia/lymphoma

  • ---Extranodal NK/T cell lymphoma, nasal type

  • ---Enteropathy-type T cell lymphoma

  • ---Hepatosplenic T cell lymphoma

  • ---Blastic NK cell lymphoma

  • ---Mycosis fungoides/Sezary syndrome

  • ---Primary cutaneous CD30-positive T cell lymphoproliferative disorders


  • --Primary cutaneous anaplastic large cell lymphoma


  • --Lymphomatoid papulosis

  • ---Angioimmunoblastic T cell lymphoma

  • ---Peripheral T cell lymphoma, unspecified

  • ---Anaplastic large cell lymphoma

  • Hodgkin Lymphoma

  • ---Nodular lymphocyte-predominant Hodgkin lymphoma

  • ---Classical Hodgkin lymphoma


  • --Nodular sclerosis


  • --Mixed cellularity


  • --Lymphocyte-rich


  • --Lymphocyte depleted

  • Immunodeficiency-Associated Lymphoproliferative Disorders

  • ---Associated with a primary immune disorder

  • ---Associated with the Human Immunodeficiency Virus (HIV)

  • ---Post-transplant

  • ---Associated with Methotrexate therapy

  • Histiocytic and Dendritic Cell Neoplasms

  • ---Histiocytic sarcoma

  • ---Langerhans cell histiocytosis

  • ---Langerhans cell sarcoma

  • ---Interdigitating dendritic cell sarcoma/tumour

  • ---Follicular dendritic cell sarcoma/tumour

  • ---Dendritic cell sarcoma, unspecified



Working Formulation

The Working Formulation, published in 1982, is primarily descriptive. It is still occasionally used, but has been superceded by the WHO classification, above.


Low grade



Intermediate grade

  • Malignant Lymphoma, follicular, predominantly large cell

  • Malignant Lymphoma, Diffuse , small cleaved cells

  • Malignant Lymphoma, diffuse, mixed (small and large cells)

  • Malignant Lymphoma, diffuse large cells

  • High grade



Miscellaneous



Other classification systems



PREVALENCE

According to the U.S. National Institutes Of Health , lymphomas account for about five percent of all cases of cancer in the United States, and Hodgkin's disease in particular accounts for less than one percent of all cases of cancer in the United States.

Because the lymphatic system is part of the body's immune system, patients with weakened immune system, such as from HIV infection or from certain drugs or medication, also have a higher incidence of lymphoma.


SEE ALSO



EXTERNAL LINKS


General



WHO classification